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Advanced filters: Author: Linhao Ruan Clear advanced filters

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

Proteins prone to aggregation in yeast are imported into mitochondria under stress conditions, suggesting that mitochondrial import and proteolysis may help to disaggregate proteins in the cytoplasm.

Linhao Ruan
Chuankai Zhou
Rong Li
Research01 Mar 2017
Nature

Volume: 543, P: 443-446
Overcoming Wnt–β-catenin dependent anticancer therapy resistance in leukaemia stem cells

Targeting resistant stem cells in leukaemia, Perry et al. show that doxorubicin at low doses decreases Akt-mediated β-catenin activity, downregulates expression of multiple immune-checkpoint genes and dampens tumorigenesis of leukaemia stem cells.

John M. Perry
Fang Tao
Linheng Li
Research20 Apr 2020
Nature Cell Biology

Volume: 22, P: 689-700
Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity

Xi Zhang
Linhao Ruan
Rong Li
ResearchOpen Access21 Jun 2024
npj Parkinson's Disease

Volume: 10, P: 1-14