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Showing 1–4 of 4 results

Advanced filters: Author: Linzehao Li Clear advanced filters

Multitrait GWAS and functional validation reveal genetic loci for gastric cancer

Multi-trait genetic analysis in East Asians identifies a novel gastric cancer risk locus shared with cardiovascular traits and shows that this variant modulates regulation of nearby genes, including VEZT, with functional effects on gastric cancer cell behaviour.

Huanxin Ding
Chuxuan Liu
Guangyong Zhang
ResearchOpen Access15 Mar 2026
Nature Communications

P: 1-17
Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East Asians

Here the authors identify genetic loci for asthma in East Asians using multi-trait GWAS. A CD36 missense variant shows protective effects and is validated through multi-omics, offering insights into asthma mechanisms and precision therapy.

Lili Zhi
Qiwen Zheng
Xiao Chang
ResearchOpen Access31 May 2025
Nature Communications

Volume: 16, P: 1-10
Uncovering pleiotropic loci in allergic rhinitis and leukocyte traits through multi-trait GWAS

Liulin Yang
Bichen Peng
Lei Shao
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders

Genetics and transcriptomics reveal shared mechanisms of psychiatric and gastrointestinal disorders, highlighting neurological pathways and pleiotropic loci. Genes BSN, CELF4, NRXN1 regulate gut-brain axis, revealing potential therapeutic targets.

Huanxin Ding
Yue Jiang
Xiao Chang
ResearchOpen Access14 Jan 2025
Communications Biology

Volume: 8, P: 1-14