Lafourcade et al. find that a lifelong insufficiency in dietary n-3 polyunsaturated fatty acids leads to a specific loss of long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens in mice. This was associated with impaired emotional behavior.
- Mathieu Lafourcade
- Thomas Larrieu
- Olivier J Manzoni
