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Showing 1–10 of 10 results
Advanced filters: Author: Lionel Christiaen Clear advanced filters

  • The ascidian tunicate Ciona, one of the closest relatives of the vertebrates, inhabits shallow temperate waters in the worldwide ocean. A unique combination of simple stereotyped embryogenesis, regulative post-embryonic stages and ecologically relevant diversity makes Ciona a premier model for marine systems life sciences, from cells and molecules to populations and ecosystems.

    • Lionel Christiaen
    News
    Nature Methods
    Volume: 22, P: 2467-2469

  • Neuronal precursor cells in the tunicate Ciona intestinalis are shown to delaminate and undergo directed cell migration along either side of the neural tube before differentiating into bipolar neurons, suggesting that vertebrate neural-crest-derived sensory neurons have much deeper evolutionary roots.

    • Alberto Stolfi
    • Kerrianne Ryan
    • Lionel Christiaen
    Research
    Nature
    Volume: 527, P: 371-374

  • Wang et al. map early cardiopharyngeal development in the chordate model Ciona and show that FGF–MAPK signalling maintains multipotency and promotes pharyngeal muscle fate, whereas Tbx1/10-Dach specify second heart lineage identity.

    • Wei Wang
    • Xiang Niu
    • Lionel Christiaen
    Research
    Nature Cell Biology
    Volume: 21, P: 674-686

  • Perturbations of the cardiopharyngeal mesoderm can lead to congenital defects in individuals with 22q11.2 deletion syndrome. Here the authors use single cell RNA-sequencing to identify a multilineage primed population within the mesoderm, marked by Tbx1, which has bipotent properties to form cardiac and branchiomeric muscle cells.

    • Hiroko Nomaru
    • Yang Liu
    • Bernice E. Morrow
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Numerous tissues are derived from the lateral plate mesoderm (LPM) but how this is specified is unclear. Here, the authors identify a pan-LPM reporter activity found in the zebrafish draculin (drl) gene that also shows transgenic activity in LPM-corresponding territories of several chordates, including chicken, axolotl, lamprey, Ciona, and amphioxus.

    • Karin D. Prummel
    • Christopher Hess
    • Christian Mosimann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • In Ciona, cardiopharyngeal progenitors migrate as polarized pairs of cells between the epidermis and the endoderm. Here the authors show that the endoderm secretes a particular collagen, which promotes Discoidin domain receptor activity to control cell-matrix adhesion and collective polarity.

    • Yelena Y. Bernadskaya
    • Saahil Brahmbhatt
    • Lionel Christiaen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • The fibroblast growth factor (FGF) signalling pathway specifies the fate of pigmented cells in the ascidian Ciona intestinalis. Here, the authors obtain lineage-specific transcription profiles of pigment precursor cells and identify FGF downstream genes involved in central nervous system patterning, and the specification and differentiation of pigmented cells.

    • Claudia Racioppi
    • Ashwani K. Kamal
    • Filomena Ristoratore
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-17