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Adoptive γδ T cell therapy controls cytomegalovirus infection in preclinical transplantation models

Gamma delta T cells as a therapeutic strategy have shown great promise in a range of contexts. Here the authors explore the use of a gamma delta T cell therapy in experimental models of cytomegalovirus infection.

Gabriel Marsères
Coline Gentil
Lionel Couzi
ResearchOpen Access17 Feb 2026
Nature Communications

Volume: 17, P: 1-16
An automated histological classification system for precision diagnostics of kidney allografts

A decision-support system that automates the Banff classification system for diagnosis of kidney allograft rejection leads to reclassification and correction of pathologists’ diagnoses and improves risk stratification of allograft outcomes.

Daniel Yoo
Valentin Goutaudier
Alexandre Loupy
Research04 May 2023
Nature Medicine

Volume: 29, P: 1211-1220
Complement receptor CD46 co-stimulates optimal human CD8⁺ T cell effector function via fatty acid metabolism

Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation. Here the authors show that CD46, a complement receptor expressed only in humans, is essential for inducing optimal activation and effector functions of human CD8 T cells.

Giuseppina Arbore
Erin E. West
Claudia Kemper
ResearchOpen Access10 Oct 2018
Nature Communications

Volume: 9, P: 1-15
The CD46-Jagged1 interaction is critical for human T_H1 immunity

The complement receptor CD46 and the Notch-Jagged system are important for the differentiation of helper T cells. Kemper and colleagues demonstrate that Jagged1 is a physiological ligand for CD46 and is critical for the generation of T helper type 1 cells in humans.

Gaëlle Le Friec
Devon Sheppard
Claudia Kemper
Research21 Oct 2012
Nature Immunology

Volume: 13, P: 1213-1221
Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

How γδ T cells 'see' antigen is poorly defined. Déchanet-Merville and colleagues demonstrate that a subset of γδ T cells functionally recognize the stress-associated self molecule EPCR on both virus-infected and transformed cells.

Carrie R Willcox
Vincent Pitard
Julie Déchanet-Merville
Research12 Aug 2012
Nature Immunology

Volume: 13, P: 872-879
Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate

Felipe Kenji Nakano
Anna Åkesson
Celine Vens
ResearchOpen Access02 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
Unconventional T cells and kidney disease

This Review examines the unique biological characteristics of unconventional T cells, including γδ T cells, mucosal-associated invariant T cells and natural killer T cells, and their roles in kidney injury, glomerulopathies and fibrosis. The authors also discuss the potential clinical applications of these cells, including in patients with kidney failure treated with dialysis or transplantation.

Hannah Kaminski
Lionel Couzi
Matthias Eberl
Reviews26 Aug 2021
Nature Reviews Nephrology

Volume: 17, P: 795-813
WARS1, TYMP and GBP1 display a distinctive microcirculation pattern by immunohistochemistry during antibody-mediated rejection in kidney transplantation

Bertrand Chauveau
Antoine Garric
Pierre Merville
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-14
Outcomes of targeted treatment in immunocompromised patients with asymptomatic or mild COVID-19: a retrospective study

M. Lahouati
C. Cazanave
Gaétane Wirth
ResearchOpen Access16 Sept 2023
Scientific Reports

Volume: 13, P: 1-8

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