Cancer-associated fibroblasts (CAFs) are abundant in the stroma of pancreatic ductal carcinoma (PDAC) tumors. In this study, the authors demonstrate using human samples and mouse models that senescent CAFs impair CD8+ T cell responses and may contribute to poor responsiveness to immunotherapy in PDAC.
- Benjamin Assouline
- Rachel Kahn
- Ittai Ben-Porath
