Nature Search

In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR

A high-throughput chemical screen identifies the salt-inducible kinase inhibitor HG-9-91-01 as a driver of β cell proliferation, acting through an ATF6-dependent unfolded protein response.

Jérémie Charbord
Lipeng Ren
Olov Andersson
Research20 May 2021
Nature Metabolism

Volume: 3, P: 682-700
Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults

Xiao et al. report a weaker adaptive immune response in older adults after inactivated SARS-CoV-2 vaccination compared to young adult controls, identifying altered immune cell function and decreased antigen-specific receptor repertoire diversity as potential underlying mechanisms.

Chanchan Xiao
Zhiyao Ren
Guobing Chen
ResearchOpen Access13 Mar 2023
Nature Aging

Volume: 3, P: 418-435
Reference genome assemblies reveal the origin and evolution of allohexaploid oat

A reference-quality genome assembly of hexaploid oat variety ‘Sanfensan’ and genome assemblies of its diploid and tetraploid Avena ancestors provide insights into the evolutionary history of allohexaploid oat.

Yuanying Peng
Honghai Yan
Changzhong Ren
ResearchOpen Access18 Jul 2022
Nature Genetics

Volume: 54, P: 1248-1258
A combinatory ferroelectric compound bridging simple ABO₃ and A-site-ordered quadruple perovskite

There are few reports of ferroelectricity due to symmetry breaking transition in A-site-ordered quadruple perovskites. Here, the authors find one with phase transition from a high-temperature centrosymmetric paraelectric phase to a low-temperature non-centrosymmetric ferroelectric phase in a high pressure synthesized compound.

Jianfa Zhao
Jiacheng Gao
Changqing Jin
ResearchOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1-9
Large Stokes shift fluorescent RNAs for dual-emission fluorescence and bioluminescence imaging in live cells

The Clivias are a series of small, monomeric fluorescent RNAs that emit with a large Stokes shift in the orange–red. They enable multiplexed RNA imaging in live cells and BRET-based detection of protein–RNA interactions in mice.

Li Jiang
Xin Xie
Yi Yang
Research18 Sept 2023
Nature Methods

Volume: 20, P: 1563-1572
Angular dependent anisotropic terahertz response of vertically aligned multi-walled carbon nanotube arrays with spatial dispersion

Yixuan Zhou
Yiwen E.
Li Wang
ResearchOpen Access14 Dec 2016
Scientific Reports

Volume: 6, P: 1-10
Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation

How cardiomyocytes mature and what regulates this is unclear. Here, the authors use single-cell analysis to examine how the population of murine cardiac fibroblasts changes during development and affects maturation of cardiomyocytes.

Yin Wang
Fang Yao
Li Wang
ResearchOpen Access22 May 2020
Nature Communications

Volume: 11, P: 1-18
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness

Rongkun Li
Hengchao Li
Shu-Heng Jiang
ResearchOpen Access26 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-14
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity

Inhibitor of mitochondrial transcription treatment leads to reduced oxidative phosphorylation capacity but increases fatty acid oxidation in the liver, leading to protection from obesity and related pathology.

Shan Jiang
Taolin Yuan
Nils-Göran Larsson
ResearchOpen Access30 Apr 2024
Nature Metabolism

Volume: 6, P: 1024-1035
Elevated SLC4A11 expression promotes OV progression via interaction with EGFR

Qihua Peng
Yixuan Sun
Xiaolu Zhu
ResearchOpen Access28 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Exploring the mechanism of Jinlida granules against type 2 diabetes mellitus by an integrative pharmacology strategy

Haiyan Gu
Liang Zhong
Zanchao Liu
ResearchOpen Access04 May 2024
Scientific Reports

Volume: 14, P: 1-14
Phosphorylation of FOXK2 at Thr13 and Ser30 by PDK2 sustains glycolysis through a positive feedback manner in ovarian cancer

Cancan Zhang
Yinyin Xu
Rong Zhang
ResearchOpen Access11 May 2024
Oncogene

Volume: 43, P: 1985-1999
Inhibiting Importin 4-mediated nuclear import of CEBPD enhances chemosensitivity by repression of PRKDC-driven DNA damage repair in cervical cancer

Yang Zhou
Fei Liu
Yincheng Teng
ResearchOpen Access13 Jul 2020
Oncogene

Volume: 39, P: 5633-5648

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