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Showing 1–3 of 3 results
Advanced filters: Author: Lisa E. Dorn Clear advanced filters

  • Muscle undergoes hypertrophy and atrophy in response to physiological stimuli or in pathological conditions, which is partially controlled through altered gene expression. Here the authors report that m6A methyltransferase METTL3 and mRNA m6A post-transcriptional modifications as a mechanism that regulates muscle hypertrophy and atrophy via myostatin signalling in mice.

    • Jennifer M. Petrosino
    • Scott A. Hinger
    • Federica Accornero
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency provides insufficient protection from oxidative stress, contributing to diverse human pathologies. Here, the authors identify a small molecule that increases the activity and/or stability of mutant G6PD and show that it reduces oxidative stress in zebrafish and hemolysis in isolated human erythrocytes.

    • Sunhee Hwang
    • Karen Mruk
    • Daria Mochly-Rosen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12