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Showing 1–4 of 4 results
Advanced filters: Author: Lisa M Minter Clear advanced filters

  • Triclosan (TCS), an antimicrobial agent commonly found in consumer products, has been reported to exacerbates colitis in animal models. Here, using in vitro and in vivo approaches, the authors show that gut bacterial enzymes can drive the metabolic activation and gut toxicity of TCS, highlighting an important role of intestinal microbial factors in the complex etiology of colitis.

    • Jianan Zhang
    • Morgan E. Walker
    • Guodong Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Notch proteins are known to have crucial roles in determining cell fate during lymphoid development. But now, new research indicates that Notch signalling might also be important during T-cell activation and differentiation in the periphery, as discussed in this Review.

    • Barbara A. Osborne
    • Lisa M. Minter
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 64-75

  • The Notch pathway plays multiple complex roles in cancer, exerting oncogenic or tumour-suppressive actions depending on the context. Here Miele and colleagues provide an overview of current understanding of the functions of Notch in cancer, highlighting key implications for the development of Notch-targeting therapeutics. Agents in clinical development and emerging therapeutic strategies are highlighted.

    • Samarpan Majumder
    • Judy S. Crabtree
    • Lucio Miele
    Reviews
    Nature Reviews Drug Discovery
    Volume: 20, P: 125-144