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Showing 1–4 of 4 results
Advanced filters: Author: Lisa M. Arkin Clear advanced filters

  • The variability in clinical outcomes of SARS-CoV-2 infection is partly due to deficiencies in production or response to type I interferons (IFN). Here, the authors describe a FIP200-dependent lysosomal degradation pathway, independent of canonical autophagy and type I IFN, that restricts SARS-CoV-2 replication, offering insights into critical COVID-19 pneumonia mechanisms.

    • Lili Hu
    • Renee M. van der Sluis
    • Trine H. Mogensen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23

  • Spatial transcriptomics experiments profile genome-wide gene expression at localized spots across a tissue. Here, the authors identify spot swapping, an artifact where RNA expressed at one tissue spot binds probes at another, and they propose SpotClean to adjust for it.

    • Zijian Ni
    • Aman Prasad
    • Christina Kendziorski
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Secondary bile acids are microbially produced metabolites linked to metabolic diseases. A challenge in microbiota research is to understand how bacteria collaborate to produce such bioactive molecules. Here, the authors show that adding a single low-abundance bacterial species to a community can significantly affect the metabolic output and host physiology.

    • Annika Wahlström
    • Ariel Brumbaugh
    • Fredrik Bäckhed
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • The authors show that binding of 14-3-3ζ enhances cytosolic Tau solubility by promoting phosphorylated Tau removal from microtubules, while simultaneously inhibiting Tau aggregation both directly and indirectly via suppression of condensate formation.

    • Janine Hochmair
    • Maxime C. M. van den Oetelaar
    • Susanne Wegmann
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-17