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Showing 1–4 of 4 results
Advanced filters: Author: Lisa Wissler Clear advanced filters

  • Postel et al. have determined a multidomain structure of GR in complex with ligand, DNA and a co-regulator peptide that demonstrates how GR forms a distinct architecture on DNA and how signal transmission can be modulated by the ligand pharmacophore.

    • Sandra Postel
    • Lisa Wissler
    • Karl Edman
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 286-295

  • The ligand-activated transcription factor farnesoid X receptor (FXR) acts as a cellular sensor for bile acids and is of interest as a drug target. Here the authors employ X-ray crystallography and NMR to characterize the molecular determinants of FXR agonists, antagonists and a partial agonist that drive FXR activation and antagonism.

    • Daniel Merk
    • Sridhar Sreeramulu
    • Harald Schwalbe
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The genome of the spider mite Tetranychus urticae is sequenced, providing insights into its polyphagous feeding, silk production, hormonal repertoire and reduced Hox cluster.

    • Miodrag Grbić
    • Thomas Van Leeuwen
    • Yves Van de Peer
    ResearchOpen Access
    Nature
    Volume: 479, P: 487-492