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Showing 1–4 of 4 results
Advanced filters: Author: Lisa-Marie Funk Clear advanced filters

  • A NOS bridge between cysteine and lysine residues serves as an allosteric redox switch in the transaldolase enzyme of Neisseria gonorrhoeae, demonstrating the existence of protein regulatory switches that contain covalent crosslinks other than disulfides.

    • Marie Wensien
    • Fabian Rabe von Pappenheim
    • Kai Tittmann
    Research
    Nature
    Volume: 593, P: 460-464

  • Structural and biophysical studies reveal that low-barrier hydrogen bonds enable long-range communication between the active sites of multimeric enzymes and synchronise catalysis.

    • Shaobo Dai
    • Lisa-Marie Funk
    • Kai Tittmann
    Research
    Nature
    Volume: 573, P: 609-613

  • A survey of protein structures identifies widespread lysine–cysteine cross-links in functionally diverse proteins across all domains of life and in various structural motifs, where these redox switches control enzyme catalysis and/or ligand binding.

    • Fabian Rabe von Pappenheim
    • Marie Wensien
    • Kai Tittmann
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 18, P: 368-375