Nature Search

Psychedelics elicit their effects by 5-HT_2A receptor-mediated G_i signalling

Psychedelics and their non-hallucinogenic analogues were compared, revealing that serotonin 2A receptor (5-HT_2AR)-mediated G_i signalling is essential for hallucinogenic effect, with the functional mechanisms underlying this providing insights for designing therapeutic drugs without hallucinogenic effects.

Zheng Xu
Hongshuang Wang
Zhenhua Shao
Research28 Jan 2026
Nature

P: 1-9
Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons

Disease-related premature stop codons are efficiently corrected by harnessing near-cognate tRNAs.

Nan Luo
Qiang Huang
Chengqi Yi
Research06 Mar 2024
Nature Biotechnology

Volume: 43, P: 114-123
Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor

Retrieval of a new starting active compound with a novel scaffold during early drug development is an important but challenging task. Here, the authors propose a generative deep learning model and by applying this model they discover a potent and highly selective RIPK1 inhibitor with a previously unreported scaffold.

Yueshan Li
Liting Zhang
Shengyong Yang
ResearchOpen Access12 Nov 2022
Nature Communications

Volume: 13, P: 1-18
RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer

R-spondin 2 has an important role in development but its function in cancer has not been described. In this study, Wu et al. demonstrate that R-spondin 2 is decreased in expression in colorectal cancer and this is associated with promoter methylation and inhibition of Wnt signalling.

Changjie Wu
Sunquan Qiu
Xincheng Lu
Research30 Jan 2014
Nature Communications

Volume: 5, P: 1-13
ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield

The mechanisms underlying differential chemotherapeutic response to 5-fluorouracil are not fully known. Here, the authors show that ABDH5 regulates sensitivity to 5-fluorouracil in colorectal cancer by regulating lysosome function.

Juanjuan Ou
Yuan Peng
Houjie Liang
ResearchOpen Access06 Mar 2019
Nature Communications

Volume: 10, P: 1-14
Chromosome-level genome assembly of Triplophysa bombifrons using PacBio HiFi sequencing and Hi-C technologies

Chengxin Wang
Site Luo
Shengao Chen
ResearchOpen Access31 Dec 2024
Scientific Data

Volume: 11, P: 1-8
Scoring cytokine storm by the levels of MCP-3 and IL-8 accurately distinguished COVID-19 patients with high mortality

Liting Chen
Gaoxiang Wang
Jianfeng Zhou
ResearchOpen Access14 Dec 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-3
Combined LC–MS/MS and 16S rDNA analysis on mice under high temperature and humidity and Herb Yinchen protection mechanism

Yao Wang
Jiayi Chen
Huanhuan Luo
ResearchOpen Access03 Mar 2021
Scientific Reports

Volume: 11, P: 1-15
Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms

Hui Luo
Dan Liu
Qian-fei Wang
ResearchOpen Access19 Apr 2021
European Journal of Human Genetics

Volume: 29, P: 1312-1315
Inactivation of HMGCL promotes proliferation and metastasis of nasopharyngeal carcinoma by suppressing oxidative stress

Wenqi Luo
Liting Qin
Ping Li
ResearchOpen Access20 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
Carnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer

Carnitine palmitoyltransferase 1A is found to promote the growth and proliferation of ovarian cancer cells through regulating mitochondrial dynamics by succinylating mitochondrial fission factor at lysine 302.

Yaqin Zhu
Yue Wang
Huanjie Shao
ResearchOpen Access08 Jun 2023
Communications Biology

Volume: 6, P: 1-14
A dynamic online nomogram for predicts delayed postoperative bleeding after colorectal polyp surgery

Liting Xu
Na Zhang
Qiang Li
ResearchOpen Access25 Aug 2024
Scientific Reports

Volume: 14, P: 1-10
EEG and fNIRS datasets based on Stroop task during two weeks of high-altitude exposure in new immigrants

Xiang Ji
Botao Bao
Ting Li
ResearchOpen Access08 Apr 2024
Scientific Data

Volume: 11, P: 1-8
EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma

Li Yuan
Shibing Li
Linquan Tang
ResearchOpen Access01 Feb 2022
Cell Death & Differentiation

Volume: 29, P: 1513-1527
High prevalence of Clonorchis sinensis infections and coinfection with hepatitis virus in riverside villages in northeast China

Yanhang Gao
Yanqing Li
Junqi Niu
ResearchOpen Access16 Jul 2020
Scientific Reports

Volume: 10, P: 1-9
Expression profiling of lncRNAs and mRNAs reveals regulation of muscle growth in the Pacific abalone, Haliotis discus hannai

Jianfang Huang
Xuan Luo
Caihuan Ke
ResearchOpen Access15 Nov 2018
Scientific Reports

Volume: 8, P: 1-9
Long non-coding RNA PVT1 predicts poor prognosis and induces radioresistance by regulating DNA repair and cell apoptosis in nasopharyngeal carcinoma

Yi He
Yizhou Jing
Guiyuan Li
ResearchOpen Access14 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-12
Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

Liting Chen
Xiaolu Long
Jianfeng Zhou
Correspondence03 Jul 2020
Cellular & Molecular Immunology

Volume: 17, P: 992-994

Search

Psychedelics elicit their effects by 5-HT_2A receptor-mediated G_i signalling

Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons

Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor

RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer

ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield

Chromosome-level genome assembly of Triplophysa bombifrons using PacBio HiFi sequencing and Hi-C technologies

Scoring cytokine storm by the levels of MCP-3 and IL-8 accurately distinguished COVID-19 patients with high mortality

Combined LC–MS/MS and 16S rDNA analysis on mice under high temperature and humidity and Herb Yinchen protection mechanism

Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms

Inactivation of HMGCL promotes proliferation and metastasis of nasopharyngeal carcinoma by suppressing oxidative stress

Carnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer

A dynamic online nomogram for predicts delayed postoperative bleeding after colorectal polyp surgery

EEG and fNIRS datasets based on Stroop task during two weeks of high-altitude exposure in new immigrants

EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma

High prevalence of Clonorchis sinensis infections and coinfection with hepatitis virus in riverside villages in northeast China

Expression profiling of lncRNAs and mRNAs reveals regulation of muscle growth in the Pacific abalone, Haliotis discus hannai

Long non-coding RNA PVT1 predicts poor prognosis and induces radioresistance by regulating DNA repair and cell apoptosis in nasopharyngeal carcinoma

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

Search

Quick links

Search

Filter By:

Search

Quick links