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Photocatalytic site-selective radical C(sp³)–H aminoalkylation, alkylation and arylation of silanes

Site-selective C–H functionalization of silanes is challenging because of the presence of multiple C–H bonds in the same molecule. Now a general photocatalytic site-selective radical functionalization of organosilicon compounds is reported, enabled by the β-silicon effect, which activates β-C(sp³)–H bonds. These reactions are applicable to linear and complex cyclic silanes.

Xingyi He
Yizhi Zhang
Xiao Shen
Research10 Oct 2024
Nature Synthesis

Volume: 4, P: 188-195
Circulating fatty acids and risk of hepatocellular carcinoma and chronic liver disease mortality in the UK Biobank

Different fatty acids have been associated to liver diseases. Here, the authors show that plasma levels of different circulating fatty acids are either negatively or positively associated with the risk of hepatocellular carcinoma and chronic liver disease mortality in the UK Biobank cohort.

Zhening Liu
Hangkai Huang
Chengfu Xu
ResearchOpen Access02 May 2024
Nature Communications

Volume: 15, P: 1-10
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm

Machine learning can be used to identify subtypes of psychiatric disease. Here the authors identified two neurostructural subgroups in schizophrenia, each showing reproducibility and generalizability across different collection locations and illness stages, using the SuStain algorithm.

Yuchao Jiang
Cheng Luo
Jianfeng Feng
ResearchOpen Access17 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Neuroimaging biomarkers define neurophysiological subtypes with distinct trajectories in schizophrenia

Using data-driven disease-progression modelling, Jiang, Wang, Zhou et al. characterized and replicated two distinct ‘trajectories’ of brain atrophy in patients with schizophrenia.

Yuchao Jiang
Jijun Wang
Jianfeng Feng
Research22 Mar 2023
Nature Mental Health

Volume: 1, P: 186-199
FACT caught in the act of manipulating the nucleosome

Two cryo-electron-microscopy images of the histone chaperone FACT interacting with components of nucleosomes shed light on how FACT manipulates nucleosomes to promote transcription, DNA repair and DNA replication.

Yang Liu
Keda Zhou
Karolin Luger
Research27 Nov 2019
Nature

Volume: 577, P: 426-431
Identification of RELN variation p.Thr3192Ser in a Chinese family with schizophrenia

Zhifan Zhou
Zhengmao Hu
Lu Shen
ResearchOpen Access13 Apr 2016
Scientific Reports

Volume: 6, P: 1-7
A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia

Achalasia is a rare motility disorder of the esophagus resulting from abnormal immune responses, but the immunologic mechanism is unclear. Here the authors use scRNA-seq of PBMC and esophageal lower sphincter tissue and find C1QC⁺ macrophages and tissue-resident memory T cells with expanded compositions and altered transcriptional profiles in achalasia.

Zu-Qiang Liu
Hao Dai
Quan-Lin Li
ResearchOpen Access04 Aug 2023
Nature Communications

Volume: 14, P: 1-19
Histidine triad nucleotide-binding protein 2 attenuates metabolic dysfunction-associated steatotic liver disease through NAD⁺-dependent sirtuin-3 activation

Qinqiu Wang
Yanjun Guo
Chengfu Xu
ResearchOpen Access01 May 2025
Experimental & Molecular Medicine

Volume: 57, P: 990-1004
Inefficient DMN Suppression in Schizophrenia Patients with Impaired Cognitive Function but not Patients with Preserved Cognitive Function

Li Zhou
Weidan Pu
Zhening Liu
ResearchOpen Access17 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Associations between polygenic risk, negative symptoms, and functional connectome topology during a working memory task in early-onset schizophrenia

Mengjie Deng
Zhening Liu
Lena Palaniyappan
ResearchOpen Access02 Jun 2022
Schizophrenia

Volume: 8, P: 1-7
Prognostic associations of cortical gyrification in minimally medicated schizophrenia in an early intervention setting

Pan Yunzhi
Xudong Chen
Lena Palaniyappan
ResearchOpen Access29 Oct 2022
Schizophrenia

Volume: 8, P: 1-10

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Photocatalytic site-selective radical C(sp³)–H aminoalkylation, alkylation and arylation of silanes

Circulating fatty acids and risk of hepatocellular carcinoma and chronic liver disease mortality in the UK Biobank

Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm

Neuroimaging biomarkers define neurophysiological subtypes with distinct trajectories in schizophrenia

FACT caught in the act of manipulating the nucleosome

Identification of RELN variation p.Thr3192Ser in a Chinese family with schizophrenia

A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia

Histidine triad nucleotide-binding protein 2 attenuates metabolic dysfunction-associated steatotic liver disease through NAD⁺-dependent sirtuin-3 activation

Inefficient DMN Suppression in Schizophrenia Patients with Impaired Cognitive Function but not Patients with Preserved Cognitive Function

Associations between polygenic risk, negative symptoms, and functional connectome topology during a working memory task in early-onset schizophrenia

Prognostic associations of cortical gyrification in minimally medicated schizophrenia in an early intervention setting

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