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Showing 1–5 of 5 results
Advanced filters: Author: Loan Vulliard Clear advanced filters

  • Profiling assays measure thousands of features to uncover biological insights but lack reliable methods for quality evaluation. Here, the authors develop a versatile information retrieval framework to robustly quantify sample activity and similarity in large-scale profiling data.

    • Alexandr A. Kalinin
    • John Arevalo
    • Shantanu Singh
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Spatial omics reveal tissue structures and can aid patient stratification. The authors present a method to identify patterns in tissue patches, enabling analysis of disease progression and treatment response, while providing insights into spatial coordination at the cell-type or marker level.

    • Jovan Tanevski
    • Loan Vulliard
    • Julio Saez-Rodriguez
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Comprehensive understanding of the human protein-protein interaction network, aka the human interactome, can provide important insights into the molecular mechanisms of complex biological processes and diseases. Here the authors summarize the community efforts initiated by the International Network Medicine Consortium to benchmark the ability of 26 representative network-based methods to predict protein-protein interactions.

    • Xu-Wen Wang
    • Lorenzo Madeddu
    • Yang-Yu Liu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational impact for strategies utilizing systemic arginine depletion in MGC-mediated diseases.

    • Julia S. Brunner
    • Loan Vulliard
    • Gernot Schabbauer
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15