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Showing 1–3 of 3 results
Advanced filters: Author: Loes van Schie Clear advanced filters

  • Here the authors characterize a single-domain antibody that broadly neutralizes SARS-CoV-2 variants with high potency by targeting the heptad repeat 2 (HR2) coiled coil, conserved in sarbecoviruses. Binding to its quaternary epitope blocks membrane fusion, by locking HR2 in its prefusion conformation.

    • Sieglinde De Cae
    • Inge Van Molle
    • Bert Schepens
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • Thymic stromal lymphopoietin (TSLP) is a cytokine critical for the development of chronic inflammatory disorders including asthma and atopic dermatitis. The structure of the ternary complex formed by TSLP and its coreceptors TSLPR and the interleukin-7 receptor reveal how TSLP is able to organize receptor-receptor contacts to facilitate intracellular signaling.

    • Kenneth Verstraete
    • Loes van Schie
    • Savvas N Savvides
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 375-382