Anti-cancer immunity relies on the effector functions (e.g., IFNγ production) of T cells that reside in a hypoxic tumor microenvironment. Here, the authors show that HIF1α-controlled glycolysis is an important driver of IFNγ production in hypoxic T cells, governing anti-tumor immunity.
- Hongxing Shen
- Oluwagbemiga A. Ojo
- Lewis Zhichang Shi
