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Showing 1–18 of 18 results
Advanced filters: Author: Lonnie Thompson Clear advanced filters

  • Analysis of Holocene climate forcing mechanisms suggests a general agreement between ice core oxygen isotope records and climate models in Greenland and West Antarctica. However, contrasting model-data isotopic trends in tropical mountains challenge interpretations and call for further investigation by the paleoclimate community.

    • Yuntao Bao
    • Zhengyu Liu
    • Jiuyou Lu
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 6, P: 1-12

  • Glacial melting in the Tibetan Plateau affects the water resources of millions of people. This study finds that—partly owing to changes in atmospheric circulations and precipitation patterns—the most intensive glacier shrinkage is in the Himalayan region, whereas glacial retreat in the Pamir Plateau region is less apparent.

    • Tandong Yao
    • Lonnie Thompson
    • Daniel Joswiak
    Research
    Nature Climate Change
    Volume: 2, P: 663-667

  • Emissions from Chinese gasoline was the primary source of lead from 1974 to 2007 reaching the Tibetan plateau glaciated regions, while emissions from coal and ores were the primary sources after 2007, according to analysis of lead isotopes of ice cores from the Guliya ice cap, and Bayesian models.

    • M. Roxana Sierra-Hernández
    • Franco Marcantonio
    • Lonnie G. Thompson
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 5, P: 1-12

  • Third Pole Environment programme was established to characterize Earth System interactions over the broader Tibetan Plateau region. Despite past successes, more insight and actionable knowledge are needed, particularly regarding the Asian Water Tower’s imbalance and associated ecosystem feedbacks and geohazards, and the teleconnections between the Third Pole and other regions.

    • Tandong Yao
    • Lonnie Thompson
    • Shilong Piao
    Comments & Opinion
    Nature Reviews Earth & Environment
    Volume: 3, P: 608-610

  • The autism spectrum disorders are complex genetic traits characterized by various neurodevelopmental deficits. Here, the authors analyse defective gene family interaction networks in autism cases and healthy controls and identify potential gene family interactions that may contribute to autism aetiology.

    • Dexter Hadley
    • Zhi-liang Wu
    • Hakon Hakonarson
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10

  • The autistic spectrum disorders (ASDs) are highly heritable, yet the underlying genetic determinants remain largely unknown. Here, a genome-wide analysis of rare copy number variants (CNVs) has been carried out, revealing that ASD sufferers carry a higher load of rare, genic CNVs than do controls. Many of these CNVs are de novo and inherited. The results implicate several novel genes in ASDs, and point to the importance of cellular proliferation, projection and motility, as well as specific signalling pathways, in these disorders.

    • Dalila Pinto
    • Alistair T. Pagnamenta
    • Catalina Betancur
    Research
    Nature
    Volume: 466, P: 368-372

  • Yuen et al. developed a cloud-based database with 5,205 whole genomes from families with autism spectrum disorder (ASD). They identified 18 new candidate ASD-risk genes and approximately 100 risk genes and copy-number loci, which account for 11% of the cases. They also found that individuals bearing mutations in ASD-risk genes had lower adaptive ability.

    • Ryan K C Yuen
    • Daniele Merico
    • Stephen W Scherer
    Research
    Nature Neuroscience
    Volume: 20, P: 602-611

  • Atmospheric warming has imbalanced the Hindu Kush–Karakoram–Himalayan system (the Asian water tower (AWT)). Yao et al. review observed changes in atmospheric water and freshwater AWT constituents, focusing on their future consequences for freshwater resources and vulnerable societies across downstream basins.

    • Tandong Yao
    • Tobias Bolch
    • Ping Zhao
    Reviews
    Nature Reviews Earth & Environment
    Volume: 3, P: 618-632

  • Elise Robinson and colleagues present the polygenic transmission disequilibrium test (pTDT) for evaluating transmission of polygenic risk in family-based study designs. The authors apply pTDT to a cohort of autism spectrum disorder (ASD) families and find that common polygenic variation acts additively with de novo variants to contribute to ASD risk.

    • Daniel J Weiner
    • Emilie M Wigdor
    • Elise B Robinson
    Research
    Nature Genetics
    Volume: 49, P: 978-985

  • Autism is a highly heritable neurodevelopmental disorder, and yet few specific susceptibility genes have been identified to date. A linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms is now described in a common set of 1,031 multiplex autism families. The linkage regions identified provide targets for rare variation screening whereas the discovery of a single novel association, SEMA5A, demonstrates the action of common variants.

    • Lauren A. Weiss
    • Dan E. Arking
    • Leena Peltonen
    Research
    Nature
    Volume: 461, P: 802-808