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Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus

Corticotropin-releasing hormone (CRH), known for activating the HPA axis during stress, also acts centrally in the brain. Here, the authors show that CRH modulates thalamic activity involved in sleep spindle generation, disrupting sleep consolidation.

Loredana Cumpana
Olivia Zanoletti
Simone Astori
ResearchOpen Access19 Aug 2025
Nature Communications

Volume: 16, P: 1-18

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Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus

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