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Showing 1–6 of 6 results
Advanced filters: Author: Loren Dean Williams Clear advanced filters

  • Removing Mg2+ from RNA and replacing it with Fe2+ confers on some RNAs the ability to catalyse single-electron transfer. Here, it is hypothesized that Fe2+ was an RNA cofactor on the early Earth, when iron was benign and abundant, and was replaced by Mg2+ during a period known as the great oxidation, brought on by photosynthesis.

    • Chiaolong Hsiao
    • I-Chun Chou
    • Loren Dean Williams
    Research
    Nature Chemistry
    Volume: 5, P: 525-528

  • Origins-of-life research has focused on specific chemical reactions that might lead to biological molecules. Now an experimental model of chemical evolution based on oscillating water activity has been established. This system undergoes continuous chemical change, and demonstrates combinatorial compression, stringent chemical selection and synchronicity of molecular populations.

    • Kavita Matange
    • Vahab Rajaei
    • Moran Frenkel-Pinter
    Research
    Nature Chemistry
    Volume: 17, P: 590-597

  • Cooperative relationships are widespread among different classes of biopolymers and are predicted to have existed during emergence of life. This study shows that proto-peptides engage in mutually stabilizing interactions with RNA, providing support for the co-evolution of these molecules.

    • Moran Frenkel-Pinter
    • Jay W. Haynes
    • Luke J. Leman
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • One of the early processes enabling the origins of life is thought to be the condensation of building blocks into oligomers and polymers. In this article, the authors report the synthesis of thiodepsipeptides and HS-peptides under mild temperatures and various pH, suggesting they could have formed on early prebiotic Earth.

    • Moran Frenkel-Pinter
    • Marcos Bouza
    • Aikomari Guzman-Martinez
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • Non-coding RNA function is poorly understood, partly due to the challenge of determining RNA secondary (2D) structure. Here, the authors present a framework for the reproducible prediction and visualization of the 2D structure of a wide array of RNAs, which enables linking RNA sequence to function.

    • Blake A. Sweeney
    • David Hoksza
    • Anton I. Petrov
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12