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EZH2 and EED are components of the Polycomb repressive complex 2 (PRC2), a ‘writer’ complex involved in histone methylation. A stapled peptide that disrupts the EZH2-EED interaction arrests growth in PRC2-dependent leukemia cells and offers an alternative mode for EZH2 inhibition.

Cold dipolar excitons, created optically in a semiconductor bilayer structure, have been predicted to show new and interesting correlation regimes and collective quantum phases. Shiloet al.provide experimental evidence for such regimes and for a possible transition to a collective dark state.

Superconductivity has been induced in 2D electron gases, but high-field interplay between it and quantum Hall edge states remains elusive. Here the authors reach this regime by growing transparent superconducting contacts in GaAs, reporting modification of resistance in the quantum Hall regime.

Previous work has shown that helical domain walls can form between states of different spin-polarization during a ferromagnetic spin transition in the fractional quantum Hall regime. Here, the authors study the transport through a single helical domain wall and find strong deviations from a simplified theory of weakly interacting edge channels.

Composite fermions emerge in the fractional quantum Hall effect. Now, it has been shown that these objects can group into bubbles and that these can order into a lattice.

Exciton–polariton condensates have garnered interest as a means to access macroscopic displays of quantum phenomena such as Bose–Einstein condensation and superfluidity. In this work, a direct measure of the polariton–polariton interaction is obtained.

The authors report on the implementation of a photonic crystal waveguide with hyperbolic geometry supporting bound-in-the continuum exciton-polariton condensates. This unveils the coexistence of evanescent and ballistic polariton coupling behaviour with all-optical control.

In most electrical conductors, heat is transported by charge carriers and so both usually flow in the same direction; but in two-dimensional electron systems subject to strong magnetic fields, certain fractional quantum Hall states can cause charge and heat to flow in opposite directions.

The Berezinskii–Kosterlitz–Thouless transition is observed in a 2D gas of exciton-polaritons, through measurements of the first-order coherence both in space and time.

An improved version of the GCaMP genetically encoded calcium indicator, called GCaMP3, has higher calcium affinity and increased baseline fluorescence, dynamic range and stability. GCaMP3 performs better than existing genetically encoded calcium indicators in several assays and organisms, including in vivo imaging of neuronal signaling in worms, flies and mice.

Through inelastic light scattering chiral spin-2 long-wavelength magnetorotons are observed, revealing chiral graviton modes in fractional quantum Hall states and aiding in understanding the quantum metric impacts in topological correlated systems.

Bound-states-in-the-continuum (BICs) display unique features like symmetry protection from dissipation, long lifetimes and topological charges. Here the authors demonstrate anisotropic Bogoliubov excitation spectrum of polariton condensate from a BIC using a patterned semiconductor GaAs/AlGaAs waveguide.

Experimental evidence is presented for a new implementation of supersolidity in a driven-dissipative, non-equilibrium context realized in a photonic-crystal waveguide, demonstrating the breaking of translational symmetry with exceptionally low losses.

The optical nature of exciton-polaritons enables new types of devices that leverage coherent quantum effects. Here the authors demonstrate a ring-shaped Josephson junction on a solid-state exciton-polariton platform, addressing challenges in generating polariton currents and providing optical access to the quantum phase. This advancement brings new possibilities for integrating the Josephson effect into photonic circuitry.

A semiconductor platform for experimentally investigating the multiorbital Bose–Hubbard model with long-range interactions is demonstrated. The interactions between the excitons are strong enough to reach the Mott insulator regime.

Four electrons in a semiconductor quantum dot exhibit similar correlation effects to those found in a molecule. Excitations of these electrons can be probed by inelastic light scattering, which reveals a decoupling of their rigid rotational motion from their spin excitations.

This study measures 'puddles' of charge in a fractional quantum Hall device and finds new evidence for the existence of quarter charge particles, thereby boosting confidence in the prospects for topological quantum computation.

Propelled by the recent renaissance of oxides, a material has emerged with sufficient purity and perfection to join those select materials that show the fractional quantum Hall effect: ZnO.

Resonances in the tunnelling spectra of a two-dimensional electron system provide strong evidence that the electrons arrange themselves into a Wigner crystal lattice with long-range ordering.

Bound states in the continuum are topological states with useful symmetry protection properties. An experiment now shows how to use them to form macroscopically coherent complexes of polariton condensates.

Many aspects of polariton condensate behaviour can be captured by mean-field theories but interactions introduce additional quantum effects. Here the authors observe quantum depletion in a driven-dissipative condensate and find that deviations from equilibrium predictions depend on the excitonic fraction.

Two-dimensional electron gases host topological states such as fractional quantum Hall states, which often compete with correlated insulators formed due to Coulomb interactions, such as the Wigner solid. Here the authors report a re-entrant Wigner solid which forms and melts due to fractional correlations, highlighting the role of particle-hole symmetry for phase competition in the quantum Hall regime.

Advanced nanoengineering of small-period AG lattices enables the observation of a vanishing density of states that suggests the presence of massless Dirac fermions.

Luttinger-liquid theory describes interacting electrons in one dimension, so long as their energies are linear as a function of momentum. When the energies become nonlinear, particles and holes behave differently, with particles able to relax when injected into a quantum wire.

The attribution of negative longitudinal magnetoresistance (NLMR) in Weyl metals to a chiral anomaly is already challenged. Here, NLMR resembling that of Weyl metals is demonstrated in a non-Weyl-metal GaAs quantum well originating from different types of disorder.

Enhancing quantum coherence is key for developing applied hybrid quantum technologies. Here, the authors optimize quantum coherence in exciton-polariton condensates by minimizing, via spatial separation, the condensate’s interaction with surrounding excitons and free carriers, thereby paving the way for integrating polariton systems into hybrid quantum devices.

Artificial nanostructures designed to simulate models of materials such as graphene provide insights into the material physics but can also have practical advantages. Du et al. create low-disorder artificial graphene devices, and present evidence of terahertz spin-exciton modes and large Coulomb interactions.

Polariton condensates undergo continuous driving and dissipation, posing challenges for investigating their collective behaviour. Ballarini et al. adapt an oceanographic technique to measure the asymmetric occupation of the Goldstone mode and identify similarities with equilibrium condensates.

'Spaghetti monster' fluorescent proteins combine the power of conventional fluorescent proteins with the benefits of commonly used epitopes. These probes are demonstrated to be extremely versatile in diverse imaging applications.

All-optical control of the topological excitations of a superfluid of light is demonstrated in a high-quality-factor semiconductor microcavity. Recovery of superfluid behaviour at high polariton densities and bosonic Josephson vortices are observed.

When electrons or photons are used to detect the motion of a mechanical resonator, they exert tiny forces on the resonator, subtly changing its motion. Here, through analysis of electrical noise measurements, the authors report a striking example of such back-action where electrons tunnelling through a semiconductor quantum device cause vibrations of the host crystal, which is massive compared with the electrons — an effect comparable to a flea causing metre-scale vibrations in Mount Everest.

Both bosonic and fermionic collective states can emerge in two-dimensional semiconductor lattices, and mixing these species can further expand the landscape of quantum phases. Here, the authors report Bose–Fermi mixtures of neutral and charged excitons and the emergence of dual-density waves in an electrostatic lattice in a GaAs bilayer.