Nature Search

Common and rare variant associations with clonal haematopoiesis phenotypes

Exome sequence data from 628,388 individuals was used to identify 24 risk loci in 40,208 carriers of clonal haematopoiesis of indeterminate potential and link them to other conditions including COVID-19, cardiovascular disease and cancer.

Michael D. Kessler
Amy Damask
Eric Jorgenson
Research30 Nov 2022
Nature

Volume: 612, P: 301-309
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Hand grip strength as a proxy of muscular fitness is a clinical predictor of mortality and morbidity. In a large-scale GWA study, the authors find 16 robustly associated genetic loci that highlight roles in muscle fibre structure and function, neuronal maintenance and nervous system signal transduction.

Sara M. Willems
Daniel J. Wright
Robert A. Scott
ResearchOpen Access12 Jul 2017
Nature Communications

Volume: 8, P: 1-12
Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

Using single-cell RNA-seq, the authors produced a comprehensive atlas of the somatosensory spinal cord. They found that neuron types build the dorsal horn by a discrete layering and to be differentially engaged by noxious heat and cold.

Martin Häring
Amit Zeisel
Patrik Ernfors
Research23 Apr 2018
Nature Neuroscience

Volume: 21, P: 869-880
Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury

Annika Gross
Lotta A. P. Pack
Pavel Strnad
Research16 Aug 2018
Mucosal Immunology

Volume: 11, P: 1630-1639

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Common and rare variant associations with clonal haematopoiesis phenotypes

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury

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