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Healthy aging and muscle function are positively associated with NAD⁺ abundance in humans

The authors compared muscle metabolomes of young and older adults with different muscle health and physical activity levels. They found that aging was characterized by lower levels of NAD⁺ that were correlated with activity levels and muscle function.

Georges E. Janssens
Lotte Grevendonk
Joris Hoeks
Research17 Feb 2022
Nature Aging

Volume: 2, P: 254-263
The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress

Human RIF1 protein protects cells from DNA replication stress, through mechanisms that remain uncertain. Here the authors demonstrate that the RIF1-Long isoform interacts with BRCA1 upon extended replication stress, enabling RAD51-dependent repair of broken replication forks.

Qianqian Dong
Matthew Day
Anne D. Donaldson
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-18
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26

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