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Author Correction: CAR immune cells: design principles, resistance and the next generation

Louai Labanieh
Crystal L. Mackall
Amendments and Corrections20 Jun 2023
Nature

Volume: 619, P: E26
CAR immune cells: design principles, resistance and the next generation

This Perspective reviews recent developments in the design and use of chimeric antigen receptors in treatments for cancers and other diseases.

Louai Labanieh
Crystal L. Mackall
Reviews22 Feb 2023
Nature

Volume: 614, P: 635-648
Engineered CD47 protects T cells for enhanced antitumour immunity

Combination of TCR or CAR T cells expressing the engineered CD47 variant 47_E with anti-CD47 antibody therapy results in synergistic antitumour efficacy due to T cell resistance to clearance by macrophages, while maintaining macrophage recruitment into the tumour microenvironment.

Sean A. Yamada-Hunter
Johanna Theruvath
Crystal L. Mackall
ResearchOpen Access15 May 2024
Nature

Volume: 630, P: 457-465
Co-opting signalling molecules enables logic-gated control of CAR T cells

Logic gating is used to develop a CAR T cell platform that is highly specific and allows the activity of T cells to be restricted to the encounter of two antigens, thus reducing on-target, off-tumour toxicity.

Aidan M. Tousley
Maria Caterina Rotiroti
Robbie G. Majzner
Research08 Mar 2023
Nature

Volume: 615, P: 507-516
Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals

NanoLuc substrates with improved solubility and bioavailability, hydrofurimazine and fluorofurimazine, strongly enhance bioluminescence signals in vivo and enable bright dual-color bioluminescent imaging with AkaLuc and AkaLumine.

Yichi Su
Joel R. Walker
Michael Z. Lin
Research13 Jul 2020
Nature Methods

Volume: 17, P: 852-860
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system

G-protein-coupled receptors are a large and diverse group of eukaryotic membrane receptors. Here the authors couple GPCRs to dCas9 to link extracellular sensing to genome regulation.

Nathan H. Kipniss
P. C. Dave P. Dingal
Lei S. Qi
ResearchOpen Access20 Dec 2017
Nature Communications

Volume: 8, P: 1-10
Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

CAR T cells administered intracerebroventricularly or intratumorally exhibit more rapid kinetics, reduced systemic toxicity and greater therapeutic potency as compared to intravenously delivered CAR T cells in atypical teratoid/rhabdoid tumor xenograft mouse models.

Johanna Theruvath
Elena Sotillo
Crystal L. Mackall
Research27 Apr 2020
Nature Medicine

Volume: 26, P: 712-719
Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M⁺ diffuse midline gliomas

Lethal pediatric tumors bearing a particular histone H3 mutation upregulate the disialoganglioside GD2, thereby making these tumors susceptible to chimeric antigen receptor T cell–based immunotherapy.

Christopher W. Mount
Robbie G. Majzner
Crystal L. Mackall
Research16 Apr 2018
Nature Medicine

Volume: 24, P: 572-579
Programming CAR-T cells to kill cancer

This Review Article provides an overview of chimeric antigen receptors (CARs) for T cells and discusses engineering strategies for the design of next-generation CAR-T therapies for haematologic and solid cancers.

Louai Labanieh
Robbie G. Majzner
Crystal L. Mackall
Reviews11 Jun 2018
Nature Biomedical Engineering

Volume: 2, P: 377-391
An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy

Hunter et al. engineer a high affinity, soluble variant of leukemia inhibitory factor receptor (LIFR) to serve as a ligand trap for the LIF cytokine. They further demonstrate that this engineered LIFR exhibits improved affinity relative to the wild-type receptor, leading to better disruption of LIF signaling in cancer cells, and highlighting promise of such ligand traps as therapeutic strategy for cancer treatment.

Sean A. Hunter
Brianna J. McIntosh
Jennifer R. Cochran
ResearchOpen Access12 Apr 2021
Communications Biology

Volume: 4, P: 1-13
An engineered antibody binds a distinct epitope and is a potent inhibitor of murine and human VISTA

Nishant Mehta
Sainiteesh Maddineni
Jennifer R. Cochran
ResearchOpen Access16 Sept 2020
Scientific Reports

Volume: 10, P: 1-15
Live imaging of Aiptasia larvae, a model system for coral and anemone bleaching, using a simple microfluidic device

Will Van Treuren
Kara K. Brower
Polly M. Fordyce
ResearchOpen Access25 Jun 2019
Scientific Reports

Volume: 9, P: 1-11

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