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Showing 1–4 of 4 results
Advanced filters: Author: Louis Gadina Clear advanced filters

  • Multi component reactions (MCRs) can build complex scaffolds from multiple starting materials in just one step without purification of intermediates but until now MCRs have been discovered rather than designed. Here, the authors demonstrate an algorithmic approach based in the knowledge of reaction mechanisms and rules of physical-organic chemistry to design autonomously MCRs in large numbers.

    • Rafał Roszak
    • Louis Gadina
    • Bartosz A. Grzybowski
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • A low-cost robotic platform using mainly optical detection to quantify yields of products and by-products allows the analysis of multidimensional chemical reaction hyperspaces and networks much faster than is possible by human chemists.

    • Yankai Jia
    • Rafał Frydrych
    • Bartosz A. Grzybowski
    ResearchOpen Access
    Nature
    Volume: 645, P: 922-931

  • Computers equipped with a comprehensive knowledge-base of mechanistic steps augmented by physical-organic chemistry rules, as well as quantum mechanical and kinetic calculations, can use a reaction-network approach to analyse the mechanisms of cationic rearrangements.

    • Tomasz Klucznik
    • Leonidas-Dimitrios Syntrivanis
    • Bartosz A. Grzybowski
    Research
    Nature
    Volume: 625, P: 508-515

  • Erwin Gelfand, Andrew Snow, Joshua Milner and colleagues identify heterozygous CARD11 mutations associated with severe atopic disease in eight individuals from four families. They further show that the mutant CARD11 proteins exhibit both loss-of-function and dominant-interfering activity and that the cellular defects in patient T cells can be partially rescued by supplementing with glutamine.

    • Chi A Ma
    • Jeffrey R Stinson
    • Joshua D Milner
    Research
    Nature Genetics
    Volume: 49, P: 1192-1201