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The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

The histone H3K4 methyltransferase SET1B is recruited to a subset of hypoxia-inducible genes by the HIF complex. Loss of SET1B reduces HIF transcriptional activity in hypoxia and impairs tumor formation in xenograft models.

Brian M. Ortmann
Natalie Burrows
James A. Nathan
Research21 Jun 2021
Nature Genetics

Volume: 53, P: 1022-1035

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The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

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