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FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment

FOXA1 is a master suppressor of prostate cancer tumorigenesis and lineage plasticity. Here, the authors discover that FOXA1 loss in mice drives basal-squamous de-differentiation and remodels the tumor microenvironment characterized by immunosuppressive myeloid cell accumulation and T-cell dysfunction.

Lourdes Brea
Hongshun Shi
Jindan Yu
ResearchOpen Access28 Mar 2026
Nature Communications

P: 1-20
No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial

Exercise modulates brown adipose tissue (BAT) metabolism in murine models. Here the authors report that there is no evidence that 24 weeks of supervised exercise training modulates BAT volume or function in young sedentary adults in the ACTIBATE randomized controlled trial.

Borja Martinez-Tellez
Guillermo Sanchez-Delgado
Jonatan R. Ruiz
ResearchOpen Access12 Sept 2022
Nature Communications

Volume: 13, P: 1-12
EZH2 PROTACs outperform catalytic inhibitors in prostate cancer by targeting a methylation-independent function of PRC2

Wanqing Xie
Qi Chu
Jindan Yu
ResearchOpen Access07 Jan 2026
Oncogene

Volume: 45, P: 636-649
HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

HOXB13 suppresses a lipogenic transcriptional program in prostate cancer (PCa) through HDAC3 recruitment to enhancers. Loss of HOXB13 leads to lipid accumulation in PCa cells, promoting cell motility in vitro and xenograft tumor metastasis in vivo.

Xiaodong Lu
Ka-wing Fong
Jindan Yu
Research25 Apr 2022
Nature Genetics

Volume: 54, P: 670-683
FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A

Xiaohai Wang
Lourdes Brea
Jindan Yu
Research05 Aug 2022
Oncogene

Volume: 41, P: 4259-4270
Expanding the clinical and molecular spectrum of the CWC27-related spliceosomopathy

Alejandro J. Brea-Fernández
Paloma Cabanas
Lourdes Loidi
Research03 Sept 2019
Journal of Human Genetics

Volume: 64, P: 1133-1136
Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration

Sandra Gómez-López
Ana Valeria Martínez-Silva
Diana Escalante-Alcalde
ResearchOpen Access11 Apr 2016
Scientific Reports

Volume: 6, P: 1-13
CD24 induces changes to the surface receptors of B cell microvesicles with variable effects on their RNA and protein cargo

D. Craig Ayre
Ian C. Chute
Sherri L. Christian
ResearchOpen Access17 Aug 2017
Scientific Reports

Volume: 7, P: 1-16
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18

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FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment

No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial

EZH2 PROTACs outperform catalytic inhibitors in prostate cancer by targeting a methylation-independent function of PRC2

HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A

Expanding the clinical and molecular spectrum of the CWC27-related spliceosomopathy

Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration

CD24 induces changes to the surface receptors of B cell microvesicles with variable effects on their RNA and protein cargo

Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

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