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Showing 1–3 of 3 results
Advanced filters: Author: Luc G. Berthiaume Clear advanced filters

  • N-myristoyltransferases (NMTs) target many signaling proteins to membranes. Here the authors show an NMT inhibitor named PCLX-001 selectively kills lymphoma cells by shutting down their main survival signaling pathway and offers an additional treatment strategy for lymphoma patients.

    • Erwan Beauchamp
    • Megan C. Yap
    • Luc G. Berthiaume
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • A highly original and sensitive method using clickable bioorthogonal fatty acids and in situ proximity ligation enables the visualization of the palmitoylation of not only Wnt but also its fatty acyltransferase Porcupine in cells.

    • Luc G Berthiaume
    News & Views
    Nature Chemical Biology
    Volume: 10, P: 5-7