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Showing 1–7 of 7 results
Advanced filters: Author: Luca Cassetta Clear advanced filters

  • Treatment strategy of solid tumors requires continuous development. Here the authors develop a Macrophage Drug Conjugate (MDC) platform by loading ferritin-drug complexes to macrophages. MDC transfers the ferritin to cancer cells via ‘TRAnsfer of Iron binding protein’ (TRAIN) process and reduces tumor volume in various mouse tumor models.

    • Bartlomiej Taciak
    • Maciej Bialasek
    • Magdalena Krol
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-30

    • Lisa M. Coussens
    • Michele De Palma
    • Luca Cassetta
    Comments & Opinion
    Nature Reviews Cancer
    Volume: 23, P: 507

  • Clinical correlative data and a plethora of preclinical studies of cancers have shown that both tumour-associated and metastasis-associated macrophages play an important role in promoting cancer. In this Perspective article, Cassetta and Pollard chronologically explore the evolution of our understanding of tumour-associated macrophage biology and enabling technologies.

    • Luca Cassetta
    • Jeffrey W. Pollard
    Reviews
    Nature Reviews Cancer
    Volume: 23, P: 238-257

  • In vitro differentiation of red blood cells (RBCs) is a desirable therapy for various disorders. Here the authors develop a culture system using stem cell-derived macrophages to show that inducible expression of a transcription factor, KLF1, enhances RBC production, potentially through the induction of three soluble factors, ANGPTL7, IL33 and SERPINB2.

    • Martha Lopez-Yrigoyen
    • Cheng-Tao Yang
    • Lesley M. Forrester
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Tumour-associated macrophages (TAMs) promote cancer initiation and malignant progression. This Review evaluates current strategies to target TAMs, exploring their toxicity and compensatory mechanisms, and proposes novel strategies in light of new findings regarding macrophage biology and their mechanism of action.

    • Luca Cassetta
    • Jeffrey W. Pollard
    Reviews
    Nature Reviews Drug Discovery
    Volume: 17, P: 887-904

  • Classical inflammatory monocytes and their derivative macrophages promote tumor metastasis whereas CD8+ T and NK cells restrict tumor growth. In a recent paper published in Science, Hanna and colleagues demonstrate that another monocyte population, nonclassical patrolling monocytes, is enriched in the microvasculature of tumor-challenged lung and reduces tumor metastasis by recruiting NK cells.

    • Luca Cassetta
    • Jeffrey W Pollard
    Research Highlights
    Cell Research
    Volume: 26, P: 3-4

  • Tumor-associated macrophages (TAMs) contribute to breast cancer progression and dissemination; TAM-targeting strategies aimed at their reprogramming show promising preclinical results. In a new report Guerriero and colleagues demonstrate that a novel HDAC Class IIa inhibitor, TMP195, can reprogram monocytes and macrophages in the tumor into cells able to sustain a robust CD8 T cell-mediated anti-tumoral immune response.

    • Luca Cassetta
    • Jeffrey W Pollard
    Research Highlights
    Cell Research
    Volume: 27, P: 963-964