Nature Search

Cohesin and CTCF control the dynamics of chromosome folding

Live-cell imaging shows that interactions within topologically associating domains are transient and frequent throughout the cell cycle. Convergent CTCF sites regulate the frequency and duration of interactions, which last a few minutes on average.

Pia Mach
Pavel I. Kos
Luca Giorgetti
ResearchOpen Access05 Dec 2022
Nature Genetics

Volume: 54, P: 1907-1918
Structural organization of the inactive X chromosome in the mouse

An in-depth analysis of the structure, chromatin accessibility and expression status of the mouse inactive X (Xi) chromosome provides insights into the regulation of Xi chromosome structure, its dependence on the macrosatellite DXZ4 region, the Xist non-coding RNA, as well as the basis for topologically associating domain (TAD) formation on the Xi.

Luca Giorgetti
Bryan R. Lajoie
Job Dekker
Research18 Jul 2016
Nature

Volume: 535, P: 575-579
HP1 drives de novo 3D genome reorganization in early Drosophila embryos

The heterochromatin protein HP1 has an essential role in establishing several features of the 3D nuclear organization of the genome during early embryonic development in Drosophila.

Fides Zenk
Yinxiu Zhan
Nicola Iovino
ResearchOpen Access14 Apr 2021
Nature

Volume: 593, P: 289-293
Nonlinear control of transcription through enhancer–promoter interactions

The transcriptional effect of an enhancer depends on its contact probabilities with the promoter through a nonlinear relationship, and enhancer strength determines absolute transcription levels as well as the sensitivity of a promoter to CTCF-mediated transcriptional insulation.

Jessica Zuin
Gregory Roth
Luca Giorgetti
ResearchOpen Access13 Apr 2022
Nature

Volume: 604, P: 571-577
DamC reveals principles of chromatin folding in vivo without crosslinking and ligation

A modified version of DamID allows measurement of chromosomal interactions without crosslinking and ligation, and provides validation for the existence of TADs in mESCs.

Josef Redolfi
Yinxiu Zhan
Luca Giorgetti
Research27 May 2019
Nature Structural & Molecular Biology

Volume: 26, P: 471-480
Author Correction: Systematic assessment of ISWI subunits shows that NURF creates local accessibility for CTCF

Mario Iurlaro
Francesca Masoni
Dirk Schübeler
Amendments and CorrectionsOpen Access01 Nov 2024
Nature Genetics

Volume: 56, P: 2574-2575
Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis

Using single-molecule tracking of cohesin and CTCF during zebrafish embryogenesis, the molecular kinetics underlying chromatin architecture formation was revealed and gradual emergence of chromatin structure recapitulated by polymer simulations.

Jonas Coßmann
Pavel I. Kos
J. Christof M. Gebhardt
ResearchOpen Access21 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Spatial partitioning of the regulatory landscape of the X-inactivation centre

High-order chromatin folding in topologically associating domains has a critical role in proper long-range transcriptional control around the Xist locus, and presumably throughout the genome.

Elphège P. Nora
Bryan R. Lajoie
Edith Heard
Research11 Apr 2012
Nature

Volume: 485, P: 381-385
Systematic assessment of ISWI subunits shows that NURF creates local accessibility for CTCF

Systematic deletions of individual imitation switch (ISWI) subunits in mouse embryonic stem cell lines highlight the role of BPTF in regulating chromatin accessibility at most CTCF sites and binding at a subset, with a modest effect on its insulating function.

Mario Iurlaro
Francesca Masoni
Dirk Schübeler
ResearchOpen Access30 May 2024
Nature Genetics

Volume: 56, P: 1203-1212
A symmetric toggle switch explains the onset of random X inactivation in different mammals

Mathematical modeling and experimental validation uncovers the minimal regulatory network that ensures stable mono-allelic expression of Xist.

Verena Mutzel
Ikuhiro Okamoto
Edda G. Schulz
Research08 Apr 2019
Nature Structural & Molecular Biology

Volume: 26, P: 350-360
The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist

Swapping the Xist/Tsix transcriptional units and placing their promoters in each other’s topologically associating domain shows that the topological partitioning of the X-inactivation center is critical to ensure proper X inactivation during development.

Joke G. van Bemmel
Rafael Galupa
Edith Heard
Research27 May 2019
Nature Genetics

Volume: 51, P: 1024-1034
Age-dependent phenotypic and molecular evolution of pediatric MDS arising from GATA2 deficiency

Lili Kotmayer
Emilia J. Kozyra
Marcin W. Wlodarski
ResearchOpen Access15 Jul 2025
Blood Cancer Journal

Volume: 15, P: 1-11
Surfactant protein B and A concentrations are increased in neonatal pneumonia

Sara D’Aronco
Manuela Simonato
Paola E. Cogo
Research24 Jun 2015
Pediatric Research

Volume: 78, P: 401-406
Challenges and guidelines toward 4D nucleome data and model standards

Marc A. Marti-Renom
Genevieve Almouzni
Maria-Elena Torres-Padilla
Reviews27 Sept 2018
Nature Genetics

Volume: 50, P: 1352-1358
In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study

Diletta Ami
Francesca Lavatelli
Giampaolo Merlini
ResearchOpen Access04 Jul 2016
Scientific Reports

Volume: 6, P: 1-12
Assessment of the structural and functional characteristics of human mesenchymal stem cells associated with a prolonged exposure of morphine

Francesco Carano
Gabriella Teti
Mirella Falconi
ResearchOpen Access28 Sept 2021
Scientific Reports

Volume: 11, P: 1-12
Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning

Camilla Pellegrini
Marta Columbaro
Giovanna Lattanzi
ResearchOpen Access02 Aug 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-17
The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

Camille Loubiere
Stephan Clavel
Frederic Bost
ResearchOpen Access11 Jul 2017
Scientific Reports

Volume: 7, P: 1-9

Search

Cohesin and CTCF control the dynamics of chromosome folding

Structural organization of the inactive X chromosome in the mouse

HP1 drives de novo 3D genome reorganization in early Drosophila embryos

Nonlinear control of transcription through enhancer–promoter interactions

DamC reveals principles of chromatin folding in vivo without crosslinking and ligation

Author Correction: Systematic assessment of ISWI subunits shows that NURF creates local accessibility for CTCF

Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis

Spatial partitioning of the regulatory landscape of the X-inactivation centre

Systematic assessment of ISWI subunits shows that NURF creates local accessibility for CTCF

A symmetric toggle switch explains the onset of random X inactivation in different mammals

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist

Age-dependent phenotypic and molecular evolution of pediatric MDS arising from GATA2 deficiency

Surfactant protein B and A concentrations are increased in neonatal pneumonia

Challenges and guidelines toward 4D nucleome data and model standards

In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study

Assessment of the structural and functional characteristics of human mesenchymal stem cells associated with a prolonged exposure of morphine

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

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