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Showing 1–5 of 5 results
Advanced filters: Author: Lucas B. Dillard Clear advanced filters

  • Nsp15 is a uridine specific endoribonuclease present in all coronaviruses. Here, the authors determine the cryo-EM structures of SARS-CoV-2 Nsp15 in the apo and UTP-bound states, which together with biochemical experiments, mass spectrometry and molecular dynamics simulations provide insights into the catalytic mechanism of Nsp15 and its conformational dynamics.

    • Monica C. Pillon
    • Meredith N. Frazier
    • Robin E. Stanley
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • PUF proteins, conserved stem cell regulators, maintain germline stem cells with partner proteins in nematodes. Here, authors discover a complex of two FBF-2 PUF proteins and partner LST-1 that represses target mRNA via adjacent regulatory elements.

    • Chen Qiu
    • Sarah L. Crittenden
    • Traci M. Tanaka Hall
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Kumar and colleagues report cryo-EM structures of Arabidopsis O-fucosyltransferase SPINDLY in its apo and GDP-fucose bound states, revealing distinct active-site features enabling GDP-fucose recognition and surprisingly dynamic conformations that regulate its enzymatic activity.

    • Shivesh Kumar
    • Yan Wang
    • Pei Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • In this work, the authors report the use of a computationally and rationally designed self-assembling peptide that has robust antiviral capability with demonstrated specificity in binding to SARS-CoV-2 and inhibition of viral entry into human cells.

    • Joseph Dodd-o
    • Abhishek Roy
    • Vivek Kumar
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Cryo-electron microscopy and crystal structures of Arabidopsis NPR1—a bird-shaped homodimer—and its complex with the transcription factor TGA3 provide an explanation for a direct role of salicylic acid and enhanceosome assembly in regulating NPR1-dependent gene expression.

    • Shivesh Kumar
    • Raul Zavaliev
    • Pei Zhou
    Research
    Nature
    Volume: 605, P: 561-566