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Showing 1–3 of 3 results
Advanced filters: Author: Lucas Nivon Clear advanced filters

  • CRISPR-mediated genome editing tools are entering the clinic, but concerns remain about the potential immunogenicity of these bacterial-derived proteins. Here, Raghavan et al. engineer two Cas effectors, Cas9 and Cas12, for reduced immunogenicity in vivo while maintaining on-target activity.

    • Rumya Raghavan
    • Mirco J. Friedrich
    • Feng Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Baker, Marcos and colleagues analyze β-arches (loops connecting unpaired β-strands) and derive rules used for de novo design of a hyperthermostable jellyroll structure, with eight antiparallel β-strands forming double-stranded β-helices.

    • Enrique Marcos
    • Tamuka M. Chidyausiku
    • David Baker
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 1028-1034