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Advanced filters: Author: Lucia Ichino Clear advanced filters

An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics

Pollen vegetative cells undergo epigenetic reprogramming, including DNA demethylation. In these cells, the authors show that the methyl readers MBD5 and MBD6 help prevent excessive demethylation by antagonizing MBD7-mediated active demethylation.

Colette L. Picard
Lucia Ichino
Steven E. Jacobsen
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-19
MBD2 couples DNA methylation to transposable element silencing during male gametogenesis

Transposable element proliferation poses considerable threats to genomes. A previously unknown methyl reader, MBD2, represses transposable elements during male gametogenesis. MBD2 acts with a high degree of redundancy with other silencing pathways, together preserving genome stability.

Shuya Wang
Ming Wang
Steven E. Jacobsen
ResearchOpen Access15 Jan 2024
Nature Plants

Volume: 10, P: 13-24

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An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics

MBD2 couples DNA methylation to transposable element silencing during male gametogenesis

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