Epis and Varotto-Boccazzi et al. show that Wolbachia surface protein (WSP) activates host innate immunity in mosquitoes, inhibiting the development of the heartworm parasite in its insect host. This study suggests the possibility that the WSP-expressing symbiont may be harnessed to control mosquito-borne diseases.
- Sara Epis
- Ilaria Varotto-Boccazzi
- Claudio Bandi