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Showing 1–8 of 8 results
Advanced filters: Author: Lucie Delemotte Clear advanced filters

  • New structural work sheds light on the architecture of otopetrin channels, offering insights into the mechanisms for proton permeation in this family.

    • Lucie Delemotte
    News & Views
    Nature Structural & Molecular Biology
    Volume: 26, P: 528-530

  • Na+ /H+ exchangers regulate intracellular pH, sodium levels, and cell volume. Cryo-EM structures reveal lipid coordination at the dimer interfaces of NhaA with cardiolipin and endosomal NHE9 with PI(3,5)P2. These findings demonstrate how specific lipids can regulate ion-exchange activity by stabilizing dimerization with physiological ramifications.

    • Surabhi Kokane
    • Ashutosh Gulati
    • David Drew
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Crystal structure of the Plasmodium falciparum hexose transporter PfHT1 reveals the molecular basis of its ability to transport multiple types of sugar as efficiently as the dedicated mammalian glucose and fructose transporters.

    • Abdul Aziz Qureshi
    • Albert Suades
    • David Drew
    Research
    Nature
    Volume: 578, P: 321-325

  • Here, Chi et al. report cryo-EM structures of the human Kv3.1a channel, revealing a unique arrangement of the cytoplasmic T1 domain, which allows the interactions with the C-terminal axonal targeting motif and key components of the gating machinery. These findings provide insights into the functional relevance of previously unknown interdomain interactions in Kv3 channels and may guide the design of new pharmaceutical drugs.

    • Gamma Chi
    • Qiansheng Liang
    • Katharina L. Dürr
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • In the Big Data era, a change of paradigm in the use of molecular dynamics is required. Trajectories should be stored under FAIR (findable, accessible, interoperable and reusable) requirements to favor its reuse by the community under an open science paradigm.

    • Rommie E. Amaro
    • Johan Åqvist
    • Modesto Orozco
    Comments & Opinion
    Nature Methods
    Volume: 22, P: 641-645