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Showing 1–2 of 2 results
Advanced filters: Author: Lucien Rufener Clear advanced filters
  • The discovery of a new chemical class of anthelmintics that seem to act through a novel mechanism is reported. These small molecules are efficacious against various livestock pathogenic-nematode species.

    • Ronald Kaminsky
    • Pierre Ducray
    • Pascal Mäser
    Research
    Nature
    Volume: 452, P: 176-180
  • Harrington et al report their discovery of Nemacol, which is a small molecule inhibitor of the vesicular acetylcholine transporter (VAChT). VAChT loads synaptic vesicles with acetylcholine and is a key point of vulnerability in animals. Harrington et al show that Nemacol has nematode selectivity and potential utility against nematode parasites.

    • Sean Harrington
    • Jacob Pyche
    • Peter J. Roy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14