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Showing 1–4 of 4 results
Advanced filters: Author: Lucile Marion-Poll Clear advanced filters

  • Some autosomal genes are expressed in a random monoallelic manner, but its extent and mechanisms have remained unclear. Here the authors show robust monoallelic expression in cell lines and mice, where the silent allele can be reexpressed using epidrugs. Further, they find these genes display various modalities of allelic expression with different degrees of allelic imbalance.

    • Lucile Marion-Poll
    • Benjamin Forêt
    • Edith Heard
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Changes in environment are known to alter reward system responses, although the underlying mechanisms are unclear. Here, Engmann et al.show that DARPP-32 interacts directly with β-adducin in the mouse striatum to regulate structural and behavioural plasticity in response to novel environment and drug exposure.

    • Olivia Engmann
    • Albert Giralt
    • Jean-Antoine Girault
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14

  • Striatal projection neurons expressing the D1 or D2 dopamine receptors are probed for translating mRNAs and DNA modifications, identifying differential methylation signatures between the cell types and genome-wide hydroxymethylation asymmetry between the two DNA strands.

    • Lucile Marion-Poll
    • Jean-Pierre Roussarie
    • Jean-Antoine Girault
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-16

  • This study shows that cocaine strengthens glutamatergic transmission, reduces K+ channel function and drives hyperexcitability in lateral habenula neurons projecting to the rostromedial tegmental nucleus. The authors also show that GluA1 trafficking mediates these cellular modifications and is instrumental in a drug-mediated depressive-like phenotype.

    • Frank J Meye
    • Kristina Valentinova
    • Manuel Mameli
    Research
    Nature Neuroscience
    Volume: 18, P: 376-378