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Dbh⁺ catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart

Catecholaminergic transmitters are critical signalling effectors known to be released by sympathetic nerves and adrenomedullary endocrine cells in response to physiological stress. In this paper, the authors demonstrate a uniquely distributed group of catecholaminergic cardiomyocytes with key regulatory roles in cardiac excitation conduction.

Tianyi Sun
Alexander Grassam-Rowe
Ming Lei
ResearchOpen Access28 Nov 2023
Nature Communications

Volume: 14, P: 1-23
Publisher Correction: Participation of ventricular trabeculae in neonatal cardiac regeneration leads to ectopic recruitment of Purkinje-like cells

Lucie Boulgakoff
Rachel Sturny
Lucile Miquerol
Amendments and Corrections11 Sept 2024
Nature Cardiovascular Research

Volume: 3, P: 1178
Participation of ventricular trabeculae in neonatal cardiac regeneration leads to ectopic recruitment of Purkinje-like cells

Boulgakoff et al. show that during cardiac regeneration, ventricular trabeculae participate in the repair of the contractile myocardium resulting in an excessive production of immature Purkinje fibers forming a hyperplastic PF network and altered ventricular conduction.

Lucie Boulgakoff
Rachel Sturny
Lucile Miquerol
Research28 Aug 2024
Nature Cardiovascular Research

Volume: 3, P: 1140-1157
Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network

Here, the authors apply genetic fate mapping and temporal clonal analysis to study progenitor recruitment and network morphogenesis of murine cardiac Purkinje fibers. Additionally, they characterize how transcription factor dosage regulates cell fate divergence during distinct phases of this process.

Caroline Choquet
Robert G. Kelly
Lucile Miquerol
ResearchOpen Access20 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Genetic targeting of Purkinje fibres by Sema3a-CreERT2

Yan Li
Xueying Tian
Bin Zhou
ResearchOpen Access05 Feb 2018
Scientific Reports

Volume: 8, P: 1-9
Cardiac arrhythmia induced by genetic silencing of ‘funny’ (f) channels is rescued by GIRK4 inactivation

The ‘funny’ current (I_f) is important for the generation and regulation of the heart’s automaticity. Here the authors show that I_f silencing through genetic modification of the f-channel component HCN4 causes heart arrhythmia by altering Ca²⁺handling in pacemaker myocytes.

Pietro Mesirca
Jacqueline Alig
Matteo E. Mangoni
Research21 Aug 2014
Nature Communications

Volume: 5, P: 1-15
Single-cell analysis of early progenitor cells that build coronary arteries

During development, new arteries can arise from pre-existing veins; the cell fate switch involved occurs gradually and before the onset of blood flow in mouse embryo hearts.

Tianying Su
Geoff Stanley
Kristy Red-Horse
Research04 Jul 2018
Nature

Volume: 559, P: 356-362
Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system

Arun Govindapillai
Adam Hotchkiss
Kishore B. S. Pasumarthi
ResearchOpen Access02 May 2018
Scientific Reports

Volume: 8, P: 1-16

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Dbh⁺ catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart

Publisher Correction: Participation of ventricular trabeculae in neonatal cardiac regeneration leads to ectopic recruitment of Purkinje-like cells

Participation of ventricular trabeculae in neonatal cardiac regeneration leads to ectopic recruitment of Purkinje-like cells

Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network

Genetic targeting of Purkinje fibres by Sema3a-CreERT2

Cardiac arrhythmia induced by genetic silencing of ‘funny’ (f) channels is rescued by GIRK4 inactivation

Single-cell analysis of early progenitor cells that build coronary arteries

Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system

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