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Showing 1–7 of 7 results
Advanced filters: Author: Lucille Lopez-Delisle Clear advanced filters

  • The regulatory landscape controlling Hoxd gene expression in tetrapod digit development was probably co-opted from a pre-existing cloacal regulatory mechanism, as evidenced by the effects of genetic deletion experiments in zebrafish fin, cloaca and mouse urogenital development.

    • Aurélie Hintermann
    • Christopher C. Bolt
    • Denis Duboule
    ResearchOpen Access
    Nature
    Volume: 648, P: 109-116

  • Mesomelic dysplasia, a severe shortening and bending of the limb, has been linked to rearrangements in the HoxD cluster in humans and mice. Here the authors engineer a 1 Mb inversion including the HoxD gene cluster and use this model to provide a mechanistic framework to understand and unify the molecular origins of human mesomelic dysplasia associated with 2q31.

    • Christopher Chase Bolt
    • Lucille Lopez-Delisle
    • Denis Duboule
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Chondrocyte differentiation controls skeleton development and stature. Here, the authors map mouse fetal chondrocyte enhancers, highlighting their role in controlling bone genes and connecting stature to non-coding variants overlapping these enhancers.

    • Fabrice Darbellay
    • Anna Ramisch
    • Guillaume Andrey
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed transcription of more posterior-located genes.

    • Hocine Rekaik
    • Lucille Lopez-Delisle
    • Denis Duboule
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 1164-1175

  • Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment provided by a topologically associated domain (TAD) located nearby. An enhancer relocated by homologous recombination takes all the hallmarks of its new neighboring enhancers located in the recipient TAD.

    • Christopher Chase Bolt
    • Lucille Lopez-Delisle
    • Denis Duboule
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15