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Showing 1–6 of 6 results
Advanced filters: Author: Lucy K. Bicks Clear advanced filters

  • Risk associated with genetically defined forms of autism spectrum disorder (ASD) can propagate by means of transcriptional regulation to affect convergently dysregulated pathways, providing insight into the convergent impact of ASD genetic risk on human neurodevelopment.

    • Aaron Gordon
    • Se-Jin Yoon
    • Daniel H. Geschwind
    ResearchOpen Access
    Nature
    Volume: 651, P: 707-719

  • Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

    • Andrew D. Grotzinger
    • Josefin Werme
    • Jordan W. Smoller
    ResearchOpen Access
    Nature
    Volume: 649, P: 406-415

  • Repeat-rich sequences play a role in 3D genome architecture in higher eukaryotes; however, this remains unexplored in brain cells. Here, the authors show that upregulation of endogenous retroviral (ERV) sequences is linked to changes in the 3D structure in the brain, which is also observed by comparison of mouse strains with recent retrotransposon expansion.

    • Sandhya Chandrasekaran
    • Sergio Espeso-Gil
    • Schahram Akbarian
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Isolation during critical periods of development prevents development of normal social behaviours in mice, and this is thought to involve the prefrontal cortex. Here, the authors identify an activation pattern in parvalbumin-positive interneurons in the dorsal medial prefrontal cortex that when activated promotes sociability behaviours in mice.

    • Lucy K. Bicks
    • Kazuhiko Yamamuro
    • Hirofumi Morishita
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Chromosome conformation is a dynamic process, especially in brain. Here, Mitchell and colleagues devise a method they call NeuroDam that can prospectively tag chromosome conformation in the mouse brain in vivo, and longitudinally assess long range chromosome looping weeks and months later.

    • Amanda C. Mitchell
    • Behnam Javidfar
    • Schahram Akbarian
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10