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Showing 1–16 of 16 results
Advanced filters: Author: Lucy R. Wedderburn Clear advanced filters

  • Juvenile idiopathic arthritis (JIA) associated uveitis can cause vision loss in children, but mechanisms remain unclear. The authors here identify elevated CD19+IgD-CD27- double negative type 1 B cells in JIA-uveitis and show that targeting B-T cell interactions suppresses disease in mouse models of uveitis.

    • Bethany R. Jebson
    • Benjamin Ingledow
    • Sarah Clarke
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-20

  • The future of rheumatology research will be defined by the growing era of personalized and stratified medicine, with a focus on establishing drug-free remission. In the face of substantial global upheaval, now is the time to ensure no patient group is left behind by prioritizing research equity and inclusion.

    • Elizabeth C. Rosser
    • Lucy R. Wedderburn
    Comments & Opinion
    Nature Reviews Rheumatology
    Volume: 21, P: 644-645

  • Transcriptomics and proteomics are transforming our understanding of juvenile idiopathic arthritis by revealing molecular signatures associated with the various clinical classifications. The challenge now is to find biomarkers that will predict disease course and response to medication in order to improve outcomes for children with arthritis.

    • Patricia J. Hunter
    • Lucy R. Wedderburn
    News & Views
    Nature Reviews Rheumatology
    Volume: 5, P: 593-594

  • Can a patient's genotype provide insight into the mechanistic basis of autoimmune disease? A study integrating epigenetic data with finely mapped disease-associated variants sheds light on how noncoding variants might alter gene expression within specific immune cells, and hints at new possibilities for individualizing treatment of autoimmune rheumatic disorders.

    • Chrysothemis C. Brown
    • Lucy R. Wedderburn
    News & Views
    Nature Reviews Rheumatology
    Volume: 11, P: 131-132

  • Anecdotal reports suggest potential severity and outcome differences between sexes following infection by SARS-CoV-2. Here, the authors perform meta-analyses of more than 3 million cases collected from global public data to demonstrate that male patients with COVID-19 are 3 times more likely to require intensive care, and have ~40% higher death rate.

    • Hannah Peckham
    • Nina M. de Gruijter
    • Claire T. Deakin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • This Review provides an overview of the clinical features and subtypes, pathophysiology and management of juvenile idiopathic inflammatory myopathies, including updates to our understanding of this heterogenous group of diseases that might change clinical practice in the near future.

    • Charalampia Papadopoulou
    • Christine Chew
    • Lucy R. Wedderburn
    Reviews
    Nature Reviews Rheumatology
    Volume: 19, P: 343-362

  • The transfer of young patients with rheumatic disease from paediatric to adult health-care provision, usually during adolescence, can have adverse effects on disease in individuals who might already be vulnerable. Herein, the authors discuss transitional health-care procedures that support and encourage young patients to take responsibility for their own health-care requirements, which might improve patient coping and disease outcomes in the long term.

    • Despina Eleftheriou
    • David A. Isenberg
    • Yiannis Ioannou
    Reviews
    Nature Reviews Rheumatology
    Volume: 10, P: 187-193

  • It is important to understand the correlates of protection against SARS-CoV-2 and its variants for future vaccine design. Here, the authors show that the complement system enhances the antibody-mediated neutralisation of SARS-CoV-2 via increased inhibition of virus-host interactions.

    • Jack Mellors
    • Raman Dhaliwal
    • Miles Carroll
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Biobanks are important tools for researchers investigating paediatric rheumatic diseases. In this Opinion article, the authors outline how standardization can improve sample and data sharing, providing examples from international biorepository networks.

    • Rae S. M. Yeung
    • Salvatore Albani
    • Lucy R. Wedderburn
    Reviews
    Nature Reviews Rheumatology
    Volume: 12, P: 684-690

  • Anne Hinks and colleagues identify 14 new susceptibility loci for juvenile idiopathic arthritis through targeted analyses of genomic regions implicated in immune function. Their study implicates several pathways, including IL-2 signaling, in the pathogenesis of this common childhood autoimmune disease.

    • Anne Hinks
    • Joanna Cobb
    • Susan D Thompson
    Research
    Nature Genetics
    Volume: 45, P: 664-669

  • This Review provides an update on autoantibodies associated with idiopathic inflammatory myopathies in both adults and children. The authors also discuss methods of autoantibody detection and the advantages and limitations of each technique.

    • Nur Azizah Allameen
    • Ana Isabel Ramos-Lisbona
    • David A. Isenberg
    Reviews
    Nature Reviews Rheumatology
    Volume: 21, P: 46-62

  • Childhood-onset arthritis has historically been treated as a separate entity to adult-onset arthritis, with its own nomenclature and classification system. Biological evidence has revealed the limitations of the current approach, necessitating a fresh look at the classification of paediatric arthritis.

    • Peter A. Nigrovic
    • Robert A. Colbert
    • Alberto Martini
    Reviews
    Nature Reviews Rheumatology
    Volume: 17, P: 257-269