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Showing 1–12 of 12 results
Advanced filters: Author: Ludger Scheja Clear advanced filters

  • Changes in the biosynthesis of fatty acids can influence tissue insulin sensitivity and the development of metabolic diseases. Eissing and colleagues show that de novolipogenesis in liver and adipose tissue is linked to metabolic health in humans and can be modulated by bariatric surgery.

    • Leah Eissing
    • Thomas Scherer
    • Ludger Scheja
    Research
    Nature Communications
    Volume: 4, P: 1-11

  • Polyunsaturated Fatty Acids (PUFA), such as omega-3 fatty acids, are recognized for their lipid lowering and anti-inflammatory properties. Here, the authors show that endogenous lipid synthesis controls the use of PUFA and thus determine the therapeutic benefit of omega-3 fatty acid supplementation.

    • Anna Worthmann
    • Julius Ridder
    • Christian Schlein
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • A new paper reports that the protein isthmin 1 is secreted by mature adipocytes and triggers a signalling cascade similar to that of insulin. The novel adipokine acts through an unidentified receptor tyrosine kinase and, at pharmacological doses in mice, isthmin 1 ameliorates metabolic disturbances associated with type 2 diabetes mellitus, including hyperglycaemia and liver steatosis.

    • Joerg Heeren
    • Ludger Scheja
    News & Views
    Nature Reviews Endocrinology
    Volume: 17, P: 709-710

  • Brown adipose tissue (BAT) produces heat by burning lipid triglycerides. Here, Berbée et al. show that pharmacological BAT activation protects hyperlipidemic mice from atherosclerosis, provided mice retain the metabolic capacity to clear cholesterol-enriched lipoprotein remnants by the liver.

    • Jimmy F. P. Berbée
    • Mariëtte R Boon
    • Patrick C.N. Rensen
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • The enzyme soluble guanylyl cyclase (sGC) regulates differentiation of brown fat. Here, Hoffman et al.show that a small molecule sGC stimulator increases brown fat activity and browning of white fat, thereby inducing energy expenditure, weight loss and partial protection from diet-induced obesity in mice.

    • Linda S. Hoffmann
    • Jennifer Etzrodt
    • Alexander Pfeifer
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose metabolism in mice.

    • Marta Pradas-Juni
    • Nils R. Hansmeier
    • Jan-Wilhelm Kornfeld
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Activation of brown adipose tissue (BAT) reduces the development of atherosclerosis in animal models. Here the authors show that BAT activation also increases reverse cholesterol transport and turnover of high-density lipoprotein, which likely contributes to the anti-atherosclerotic effect of BAT activation.

    • Alexander Bartelt
    • Clara John
    • Joerg Heeren
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • During development of myointimal hyperplasia in human arteries, smooth muscle cells have hyperpolarized mitochondrial membrane potential (ΔΨm), high proliferation and apoptosis resistance; PDK2 is a key regulatory protein whose activation is necessary for myointima formation, and its blockade with dichloroacetate prevents Δψm hyperpolarization, facilitates apoptosis and reduces myointima formation in injured arteries, without preventing vessel re-endothelialization, possibly representing a novel strategy to prevent proliferative vascular diseases.

    • Tobias Deuse
    • Xiaoqin Hua
    • Sonja Schrepfer
    Research
    Nature
    Volume: 509, P: 641-644

  • Adipocytes respond to environmental cues, such as metabolic stress, by releasing endocrine factors that modulate diverse physiological processes. This Review discusses the metabolic functions of adipose tissue-derived endocrine hormones and highlights how these factors might contribute to cardiometabolic diseases.

    • Ludger Scheja
    • Joerg Heeren
    Reviews
    Nature Reviews Endocrinology
    Volume: 15, P: 507-524