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Showing 1–7 of 7 results
Advanced filters: Author: Ludivine Grzelak Clear advanced filters

  • The molecular basis for differences in immune response to SARS-CoV-2 in children and adults is still unclear. Here, the authors show that antibodies are of high binding and functional quality in children with mild or asymptomatic infection, but antibody response is delayed as compared to adults.

    • Carolyn A. Cohen
    • Ludivine Grzelak
    • Sophie A. Valkenburg
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • In this work, Planas et al. report that Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 escape neutralization from monoclonal antibodies, and sera from vaccinated individuals with or without Omicron BA.1/2 or BA.5 breakthrough infection.

    • Delphine Planas
    • Timothée Bruel
    • Olivier Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Sera from convalescent individuals with coronavirus disease 2019 and from individuals vaccinated with BNT162b2 have reduced ability to neutralize SARS-CoV-2 variants B1.1.7 and B.1.351, but antibody potency against the variants increases after two vaccine doses.

    • Delphine Planas
    • Timothée Bruel
    • Olivier Schwartz
    Research
    Nature Medicine
    Volume: 27, P: 917-924

  • We demonstrate that the transmembrane protease TMPRSS2 is a receptor for coronavirus HKU1; it triggers HKU1-mediated cell–cell fusion and viral entry by binding to both HKU1A and HKU1B spikes.

    • Nell Saunders
    • Ignacio Fernandez
    • Olivier Schwartz
    Research
    Nature
    Volume: 624, P: 207-214

  • Mucosal surfaces of the respiratory tract are the first sites of entry and defense against SARS-CoV-2. Di Santo and colleagues perform paired analysis of the nasopharyngeal and systemic immune responses of SARS-CoV-2-infected patients and demonstrate distinct compartmentalization of immunity and shifts in the microbiome.

    • Nikaïa Smith
    • Pedro Goncalves
    • James P. Di Santo
    ResearchOpen Access
    Nature Immunology
    Volume: 22, P: 1428-1439

  • Cross-protective responses across all strains of influenza virus (IAV, IBV and ICV) are a key goal of universal vaccines against influenza. Kedzierska and colleagues identify cytotoxic T cells present in blood and lungs of healthy people that are directed against all strains of influenza virus.

    • Marios Koutsakos
    • Patricia T. Illing
    • Katherine Kedzierska
    Research
    Nature Immunology
    Volume: 20, P: 613-625