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Showing 1–4 of 4 results
Advanced filters: Author: Ludovica Lospinoso Severini Clear advanced filters

  • Despite being an important driver of a subset of medulloblastomas, efforts to therapeutically target Sonic Hedgehog (SHH) signaling, such as with the use of Smoothened (SMO) inhibitors, have had limited success. Here, the authors find that SHH medulloblastomas are sensitive to netrin-1 inhibition and investigate netrin-1 as a mechanism of resistance to SMO inhibition.

    • Julie Talbot
    • Joanna Fombonne
    • Olivier Ayrault
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from  βTrCP and promoting tumorigenesis through βTrCP degradation and increased Gli protein stability.

    • Francesca Bufalieri
    • Paola Infante
    • Lucia Di Marcotullio
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • SuFu is a tumour suppressor in medulloblastoma and regulates Gli proteins in the Sonic Hedgehog pathway; however, the molecular mechanisms behind this regulation are unclear. Here, the authors show that the Itch/β-arrestin2 complex binds and ubiquitylates SuFu, facilitating the interaction with Gli3 and its conversion into the repressive form, thus counteracting medulloblastoma formation.

    • Paola Infante
    • Roberta Faedda
    • Lucia Di Marcotullio
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17