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Showing 1–6 of 6 results
Advanced filters: Author: Luigi De Colibus Clear advanced filters

  • Enterovirus HEV71 is responsible for recurring epidemics in developing countries. New structural analyses coupled with in silico docking methods have allowed for the generation of potent inhibitors of viral-envelope uncoating that block subsequent insertion of viral RNA into the host cell.

    • Luigi De Colibus
    • Xiangxi Wang
    • David I Stuart
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 282-288

  • Here, the authors present the cryo-EM structure of the archaeal virus SH1 at 3.8 Å resolution and show how the major capsid proteins assemble into hetero-hexamers, providing insights into the assembly process of this and related PRD1-adeno lineage viruses.

    • Luigi De Colibus
    • Elina Roine
    • David I. Stuart
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • The post-transcriptional addition of uridyl ribonucleotides by terminal uridyltransferases (TUTases) to the ′A ends of various cytoplasmic RNAs, including microRNAs, has been implicated in regulating their stability, biogenesis or activity. The crystal structure of Schizosaccharomyces pombe TUTase Cid1 in its apo form and bound to UTP provides insight into the enzyme's active site, UTP selectivity and RNA-binding mechanism.

    • Luke A Yates
    • Sophie Fleurdépine
    • Robert J C Gilbert
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 782-787

  • Crystal structures and functional assays of a chimeric GABAA receptor in apo and pregnanolone-bound states reveal how neurosteroid binding alters receptor conformation to modulate channel opening.

    • Paul S Miller
    • Suzanne Scott
    • A Radu Aricescu
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 986-992

  • Structures of the adiponectin receptors ADIPOR1 and ADIPOR2 combined with molecular dynamics simulations and enzymatic assays suggest that both receptors have intrinsic ceramidase activity.

    • Ieva Vasiliauskaité-Brooks
    • Remy Sounier
    • Sébastien Granier
    Research
    Nature
    Volume: 544, P: 120-123