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Showing 1–5 of 5 results
Advanced filters: Author: Luis Leiva-Vega Clear advanced filters

  • How adipose mitochondria activity is fine-tuned in response to obesity is an active area of study. Here, the authors show that mitochondrial protein MCJ can block thermogenesis and that silencing this gene can correct obesity-related comorbidities.

    • Beatriz Cicuéndez
    • Alfonso Mora
    • Guadalupe Sabio
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The liver is segregated into spatially organized areas that serve distinct functions, though how these zones are patterned remains unclear. Here they show that mTORC1 controls spatial segregation of liver metabolic functions via modulation of Wnt signaling, and find that impaired zonation is also observed in pigs given total parenteral nutrition.

    • Ana Belén Plata-Gómez
    • Lucía de Prado-Rivas
    • Alejo Efeyan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Romero-Becerra et al. report that stress kinases p38γ and p38δ are activated in ventricles of old mice and in arrhythmogenic conditions, and they demonstrate that p38γ/δ -driven phosphorylation of RyR2 and SAP97 is a trigger for ventricular fibrillation.

    • Rafael Romero-Becerra
    • Francisco M. Cruz
    • Guadalupe Sabio
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 1204-1220

  • Brown and beige adipose tissues dissipate heat via uncoupling protein 1 (UCP1). Here the authors show that the stress activated kinase MKK6 acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure.

    • Nuria Matesanz
    • Edgar Bernardo
    • Guadalupe Sabio
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • The stress-activated kinase p38γ has a role in regulating entry into the cell cycle; in the liver, it can induce cellular proliferation during regeneration and promote the development of hepatocellular carcinoma.

    • Antonia Tomás-Loba
    • Elisa Manieri
    • Guadalupe Sabio
    Research
    Nature
    Volume: 568, P: 557-560