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Showing 1–3 of 3 results
Advanced filters: Author: Luis Ostrosky- Zeichner Clear advanced filters

  • The incidence of invasive fungal infections is increasing, and there is an unmet need for new antifungal drugs. This article provides an overview of the history of antifungal drug discovery, discusses the current pipeline and presents new vaccination and immunotherapeutic approaches to treat fungal infections.

    • Luis Ostrosky-Zeichner
    • Arturo Casadevall
    • John H. Rex
    Reviews
    Nature Reviews Drug Discovery
    Volume: 9, P: 719-727

  • Invasive candidiasis is a fungal disease caused by Candida pathogens. In this Primer, Lass-Flörl et al. summarize current knowledge of epidemiology and mechanisms and discuss the diagnosis, treatment and quality of life of patients with invasive candidiasis. They also highlight outstanding research questions.

    • Cornelia Lass-Flörl
    • Souha S. Kanj
    • Miriam Alisa Govrins
    Reviews
    Nature Reviews Disease Primers
    Volume: 10, P: 1-18

  • Candida spp. are common commensal organisms in the gut microbiota. However, breaches in the intestinal barrier, an impaired immune system, the use of broad-spectrum antibacterial agents and other interventions associated with medical progress can promote invasive Candida spp. infections, including bloodstream infections, that are often fatal.

    • Peter G. Pappas
    • Michail S. Lionakis
    • Bart Jan Kullberg
    Reviews
    Nature Reviews Disease Primers
    Volume: 4, P: 1-20