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Advanced filters: Author: Luisa Krumwiede Clear advanced filters

PET-based tracking of CAR T cells and viral gene transfer using a cell surface reporter that binds to lanthanide complexes

A cell surface reporter that binds to a fluorine-18-labelled radioligand enables the monitoring of CAR T cells and gene therapy vectors in preclinical models using PET imaging.

Volker Morath
Katja Fritschle
Wolfgang A. Weber
ResearchOpen Access13 Jun 2025
Nature Biomedical Engineering

Volume: 9, P: 1886-1906
DELE1 tracks perturbed protein import and processing in human mitochondria

Human mitochondria experience substantial stress and malfunction in neurological diseases. Here, the authors reveal DELE1 as a multimodal sensor of protein import and processing defects, rationalizing mitochondrial stress integration.

Evelyn Fessler
Luisa Krumwiede
Lucas T. Jae
ResearchOpen Access06 Apr 2022
Nature Communications

Volume: 13, P: 1-15
Non-invasive and high-throughput interrogation of exon-specific isoform expression

Truong et al. developed a cell-based reporter system, EXSISERS, that enables non-invasive quantification of the protein expression levels of exon-specific isoforms via intein-mediated protein splicing.

Dong-Jiunn Jeffery Truong
Teeradon Phlairaharn
Gil Gregor Westmeyer
ResearchOpen Access03 Jun 2021
Nature Cell Biology

Volume: 23, P: 652-663