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Showing 1–2 of 2 results
Advanced filters: Author: Lukas Bolini Clear advanced filters

  • While CDK4/6 inhibitors improved clinical outcomes in HR+HER2- metastatic breast cancer (MBC), resistance invariably occurs. The underlying molecular mechanisms are not actionable, leaving limited therapeutic options for progressing patients. Recent data highlight a role for IL-6 in the resistance of HR+HER2- MBC to CDK4/6 inhibition, potentially opening novel avenues forward.

    • Lukas Bolini
    • Joyce G. Habib
    • Lorenzo Galluzzi
    Comments & OpinionOpen Access
    npj Precision Oncology
    Volume: 9, P: 1-3

  • Radiotherapy has attracted considerable attention as a means to alter the immune cell compartment of breast malignancies in support of increased sensitivity to immunotherapy. Recent data from Schalck and colleagues corroborate the notion that dose is a critical determinant of the immunological effects of radiotherapy on the tumor microenvironment.

    • Lorenzo Galluzzi
    • Lukas Bolini
    • Rebecca M. Shulman
    Comments & OpinionOpen Access
    npj Breast Cancer
    Volume: 11, P: 1-3