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Showing 1–9 of 9 results
Advanced filters: Author: Lukasz J. Bugaj Clear advanced filters

  • The EML4-ALK oncogene forms  cytoplasmic protein condensates that are associated with its oncogenic signaling. Here, the authors demonstrate that these EML4-ALK assemblies also sequester receptor tyrosine kinase (RTK) adapter proteins suppressing signaling which was reversed upon ALK inhibition, resulting in rapid resensitisation to growth factors and tumor cell survival.

    • David Gonzalez-Martinez
    • Lee Roth
    • Lukasz J. Bugaj
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward thermogenetic control of diverse cellular processes.

    • William Benman
    • Zikang Huang
    • Lukasz J. Bugaj
    Research
    Nature Methods
    Volume: 22, P: 539-549

  • The BcLOV4 photoreceptor was used to generate single-component optogenetic signaling probes whose activation dynamics are dependent on light and temperature, allowing multiplexing of blue-light-sensitive tools in mammalian cells

    • William Benman
    • Erin E. Berlew
    • Lukasz J. Bugaj
    Research
    Nature Chemical Biology
    Volume: 18, P: 152-160

  • Targeted degradation has emerged as a powerful therapeutic modality. In this study, the authors develop a lipid-based platform to deliver recombinant bioPROTACs into cells for targeted protein degradation, providing a platform for efficient intracellular degradation of proteins that may elude chemical inhibition.

    • Alexander Chan
    • Rebecca M. Haley
    • Andrew Tsourkas
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • A modular optogenetic method for higher-order protein oligomerization uses a single cryptochrome 2-based fusion for rapid, reversible and tunable oligomerization in response to blue light. Inducible aggregation can be used to specifically activate different signaling pathways.

    • Lukasz J Bugaj
    • Atri T Choksi
    • David V Schaffer
    Research
    Nature Methods
    Volume: 10, P: 249-252

  • A protocol for the assembly and use of the optoPlate-96, a platform for high-throughput three-color optogenetics experiments in microwell plates. With the provided design files, users can assemble the optoPlate-96 from 3D-printed and laser-cut components.

    • Lukasz J. Bugaj
    • Wendell A. Lim
    Protocols
    Nature Protocols
    Volume: 14, P: 2205-2228